5-HT 2C receptors are claimed to significantly regulate mood, anxiety, feeding, and reproductive behavior. [11] 5-HT 2C receptors regulate dopamine release in the striatum, prefrontal cortex, nucleus accumbens, hippocampus, hypothalamus, and amygdala, among others.

2024年12月25日 · HTR2C (5-Hydroxytryptamine Receptor 2C) is a Protein Coding gene. Diseases associated with HTR2C include Major Depressive Disorder and Anxiety. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

2022年12月19日 · Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT2CR (HTR2C) in 19 unrelated...

2025年3月8日 · In addition, your package will include a detailed data report in both TSV and JSONL formats. This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin.

结果：通过免疫荧光染色，确定被标记的神经元为Htr2c阳性神经元，是vCA1区域的一个兴奋性神经元亚群，分布在靠近多形层的锥体细胞层的深层部分。 抑制Htr2c神经元活性，导致小鼠的注意力下降。

2022年12月22日 · 研究团队进一步确定了这种基因突变导致肥胖的具体机制，研究团队发现，五羟色胺2C受体 （5-HT 2C R） 是维持下丘脑促黑皮质激素 （POMC） 神经元正常放电活动所必需的，而这些神经元放电是抑制暴饮暴食所必需的。 当5-HT 2C R发生功能缺失突变时，POMC神经元的放电活动就会受损，就会导致暴饮暴食，从而变得肥胖。 徐勇 教授表示， 这项研究证实，5-HT 2C R功能缺失突变导致小鼠的社交能力下降，攻击性增强，在这项研究之前，几乎没有证据表 …

Restricted expression toward brain (RPKM 1.3). 该基因编码一个七次跨膜的 G 蛋白偶联受体。 编码的蛋白质通过神经递质血清素响应信号。 该基因的 mRNA 受到多个 RNA 编辑事件的影响，其中基因组编码的腺苷残基被转化为肌苷。 预计 RNA 编辑会改变第二个细胞内环的结构，从而产生与 G 蛋白相互作用能力降低的替代蛋白质形式。 已在患有抑郁症的自杀受害者中检测到该基因的 RNA 编辑异常。 此外，该基因的启动子和 5' 非编码区和编码区的自然变异可能与精神疾病和 …

HTR2C is coupled to G (q)/G 11 G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca 2+ ions from intracellular stores, respectively (PubMed: 18703043, PubMed: 29398112).

2024年12月10日 · Clinical resource with information about HTR2C, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2021年7月21日 · In this review, we introduced the regulatory role of 5-HTR2C in feeding behavior and glucose metabolism, with particular focus on the molecular pathways, neural network, and its interaction with other metabolic hormones, such as leptin, ghrelin, insulin, and estrogens.