2022年5月5日 · In this study, we found that STAT6 promoted angiogenesis, possibly by increasing the expression of neuropilin-1 (NRP1) in endothelial cells (ECs). Both STAT6 …

1999年6月1日 · We demonstrate the existence of 2 functional signal transducer and activator of transcription 6 (Stat6) binding sites on the P-selectin promoter and further demonstrate, by …

2017年1月18日 · STAT6 activation is linked to reactivation of oncogenic herpesvirus and their associated cancers. However, the precise mechanism by which KSHV modulates STAT6 …

2024年9月1日 · To confirm the requirement of IL-4–STAT6 axis in histamine-induced VE permeability, we treated HUVECs (HUV-EC-C) with vehicle or STAT6 PROTAC 1690 and …

Mechanistically, long-myosin light-chain kinase (MLCK1) was identified as a target of STAT6, leading to epithelial tight junction dysfunction and microbiota-driven colitis.

2024年5月20日 · pharmacologic knockdown of STAT6 abrogated IL-4–mediated amplification of histamine-induced hypovolemia. Conclusions: These studies unveil a novel role of the IL …

Results: IL-4 and IL-13 induced OPG mRNA levels and protein secretion in HUVEC by up to 4-fold in a dose- and time-dependent fashion (maximum effect after 48 h and at 10 ng/ml). …

2018年12月10日 · Aberrations in STAT6-mediated signaling are linked to the development of multiple cancer types. Increasing evidence has shown that activation of human oncogenic …

2024年1月1日 · Using in vitro co-culture assay, we observed an increase of Huvec migration in the presence of high pro-angiogenic factors secretion, by PD-L1 overexpressing cells, and …

2022年6月1日 · Whole cell lysate from HUVEC cells with KSHV infection (GFP positive) at different time points, were subjected to immunoblotting (IB) with antibodies as indicated in the …