Selective autophagy controls the stability of TBK1 via NEDD4 …
2021年7月13日 · Here we report that E3 ubiquitin ligase NEDD4 functions as a negative regulator of type I interferon (IFN) signaling by targeting TBK1 for degradation at the late stage of viral …
VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for ...
2023年6月23日 · During VSV infection, VANGL2 interacts with TBK1 and promotes K48-linked polyubiquitination at Lys 372 of TBK1 via E3 ligase TRIP, which serves as a recognition …
TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for …
In this study, we report a novel role of ZNF268a in facilitating antiviral innate immune signaling in the cytoplasm. We find that ZNF268a can specifically target the critical kinase TBK1 and help …
Structure and Ubiquitination-Dependent Activation of TANK …
2013年3月28日 · Upon stimulation by pathogen-associated inflammatory signals, TANK-binding kinase 1 (TBK1) induces type I interferon expression and modulates nuclear factor κB (NF-κB) …
Frk positively regulates innate antiviral immunity by phosphorylating TBK1
In this study, we validated the function of Fyn-related kinase (Frk) in the antiviral innate immune response and identified the direct target molecule of Frk in the IFN-β signaling pathway. …
TANK结合激酶1在抗病毒免疫应答中的作用研究进展
2016年5月16日 · TBK1是抗病毒固有免疫应答中促进Ⅰ型干扰素合成的关键激酶。明确TBK1激活的信号转导通路和调控机制, 可以为病毒感染、肿瘤以及一些代谢性疾病的临床预防和治疗提 …
Control of TANK-binding Kinase 1-mediated Signaling by the …
TANK-binding kinase 1 (TBK1) is a key component of Toll-like receptor-dependent and -independent signaling pathways. In response to microbial components, TBK1 activates …
Full article: TBK1 is a signaling hub in coordinating stress-adaptive ...
3 天之前 · MUL1 KO FaDu cells were transfected MYC-His-TBK1 and Flag-MUL1 together with HA-WT Ub or ubiquitin mutants (HA-Ub-K48, HA-Ub-K63, HA-Ub K48R, or HA-Ub K63R). …
TRIM28 facilitates type I interferon activation by targeting TBK1
2024年3月1日 · Our data identifies TRIM28 as a positive regulator of IFN-I activation and cellular antiviral responses downstream of cytosolic RNA and DNA PRRs. Further biochemical …
SIRT5 safeguards against primate skeletal muscle ageing via
2025年3月14日 · SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.