2015年11月19日 · As originally proposed by Cryer, HAAF is characterized by a clinical or subclinical event (recent antecedent hypoglycemia), biochemical features (defective glucose counterregulation, evidenced by attenuated glucagon and epinephrine responses), and subjective manifestations (absent or impaired awareness of neurogenic symptoms, arising from ...

2005年12月1日 · The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent antecedent iatrogenic hypoglycemia causes both defective glucose counterregulation (by reducing epinephrine responses to a given level of subsequent hypoglycemia in the setting of absent decrements in insulin and absent increments in …

The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent antecedent hypoglycemia, as well as sleep or prior exercise, causes both defective glucose counterregulation (by attenuating the adrenomedullary epinephrine response, in the setting of absent insulin and g …

2013年7月25日 · A model of HAAF in humans shows a greater increase in dorsal midline thalamus activation, as measured with the use of [15 O]water positron-emission tomography, during hypoglycemia on day 2 than...

This Profile in Progress focuses on the seminal contributions of Philip E. Cryer, MD, to our understanding of hypoglycemia and glucose counterregulation, particularly his discovery of the syndrome of hypoglycemia-associated autonomic failure (HAAF). © 2015 by the American Diabetes Association.

Philip E. Cryer, MD: Seminal Contributions to the Understanding of Hypoglycemia and Glucose Counterregulation and the Discovery of HAAF (Cryer Syndrome). Optimized glycemic control prevents and slows the progression of long-term complications in patients with type 1 …

2015年11月19日 · Marked interindividual variability in epinephrine responses to hypoglycemia may explain an individual's susceptibility to developing HAAF, which reproduce key features of HAAF in nondiabetic subjects.

2006年1月1日 · The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent antecedent hypoglycemia causes both defective glucose counterregulation (by reducing epinephrine responses in the setting of absent insulin and glucagon responses) and hypoglycemia unawareness (by reducing sympathoadrenal and the resulting neurogenic ...

2015年11月19日 · As originally proposed by Cryer, HAAF is characterized by a clinical or subclinical event (recent antecedent hypoglycemia), biochemical features (defective glucose counterregulation, evidenced by attenuated glucagon and epinephrine responses), and subjective manifestations (absent or impaired awareness of neurogenic symptoms, arising from ...

The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posited, initially, that recent antecedent hypoglycemia causes both defective glucose counterregulation (by attenuating the epinephrine response in the setting of absent insulin and glucagon responses) and hypoglycemia unawareness (by attenuating largely the sympathetic ...