2022年8月9日 · Recurring hypoglycemia leads to a condition of hypoglycemia-associated autonomic failure (HAAF). HAAF refers to a combination of (i) impaired hormonal counterregulatory responses and (ii) hypoglycemia unawareness to subsequent hypoglycemia, substantially increasing the risk of severe hypoglycemia.

Hypoglycemia-associated autonomic failure (HAAF) limits the ability of patients with diabetes to achieve target glycemia. Animal models have provided insights into the pathogenesis of HAAF, but a robust human model of HAAF in which recurrent hypoglycemia impacts the counterregulatory responses to hypoglycemia days later is lacking. Objective:

In fact, recurrent episodes of hypoglycemia lead to ‘hypoglycemia-associated autonomic failure’ (HAAF), characterized by defective counter-regulatory responses to hypoglycemia. Extensive studies to understand the mechanisms underlying HAAF have revealed multiple potential etiologies, suggesting various approaches to prevent the development ...

2022年10月4日 · Recurring hypoglycemia leads to a condition of hypoglycemia-associated autonomic failure (HAAF). HAAF refers to a combination of (i) impaired hormonal counterregulatory responses and (ii) hypoglycemia unawareness to subsequent hypoglycemia, substantially increasing the risk of severe hypoglycemia.

The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent antecedent hypoglycemia, as well as sleep or prior exercise, causes both defective glucose counterregulation (by attenuating the adrenomedullary epinephrine response, in the setting of absent insulin and g …

2014年2月1日 · Hypoglycemia-associated autonomic failure (HAAF) limits the ability of patients with diabetes to achieve target glycemia. Animal models have provided insights into the pathogenesis of HAAF, but a robust human model of HAAF in which recurrent hypoglycemia impacts the counterregulatory responses to hypoglycemia days later is lacking.

2022年8月9日 · Recurring hypoglycemia leads to a condition of hypoglycemia-associated autonomic failure (HAAF). HAAF refers to a combination of (i) impaired hormonal counterregulatory responses and (ii) hypoglycemia unawareness to subsequent hypoglycemia, substantially increasing the risk of severe hypoglycemia.

IAH 和激素反应丧失一起被称为低血糖相关自主神经衰竭 (HAAF)。 IAH 在 1 型糖尿病患者中的患病率高达 25%，在 2 型糖尿病患者中的患病率高达 10%。 IAH 和 HAAF 分别使严重低血糖的风险增加 6 倍和 25 倍。 为了降低严重低血糖的风险，正在探索多种不同的治疗方法，以提高对低血糖的认识。 目前提高低血糖意识的疗法包括患者教育和心理教育、使用新型血糖控制技术、胰腺/胰岛移植和药物治疗。 本综述检查了现有疗法和处于临床前测试中的潜在疗法。 通过改善反调 …

2005年12月1日 · The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent antecedent iatrogenic hypoglycemia causes both defective glucose counterregulation (by reducing epinephrine responses to a given level of subsequent hypoglycemia in the setting of absent decrements in insulin and absent increments in …

2015年8月28日 · Hypoglycemia-associated autonomic failure (HAAF), which is characterized by defective glucose counterregulation during hypoglycemia, is a well-known neuroendocrine complication in children and adults on insulin therapy for type 1 and type 2 diabetes [2,3].