2024年12月25日 · HABP2 (Hyaluronan Binding Protein 2) is a Protein Coding gene. Diseases associated with HABP2 include Thyroid Cancer, Nonmedullary, 5 and Thrombophilia Due To Thrombin Defect . Gene Ontology (GO) annotations related to this gene include calcium ion binding and glycosaminoglycan binding .

Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene. [5] [6] [7] The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion.

2009年12月30日 · HABP2, also called factor VII–activating protease, is an extracellular serine protease involved in the extrinsic pathway of blood coagulation (via activation of factor VII) and fibrinolysis (via activation of prourokinase type plasminogen activator). 4,6 HABP2 has been implicated in several disease processes, including atherosclerosis and ...

该基因编码丝氨酸蛋白酶肽酶 S1 家族的成员。 编码的前原蛋白由肝细胞分泌并经过蛋白水解处理以产生形成成熟异二聚体的重链和轻链。 进一步的自身蛋白水解导致更小的无活性肽。 这种细胞外蛋白酶结合透明质酸，并可能在凝血和纤维蛋白溶解系统中发挥作用。 该基因的突变与非髓样甲状腺癌和静脉血栓栓塞症的易感性有关。 选择性剪接会产生多种转录物变体，其中至少一种会编码经过蛋白水解处理的前原蛋白。 [RefSeq 提供，2016 年 1 月] This gene encodes a member …

Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA/Rho kinase signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability.

2025年2月8日 · HABP2 Marburg-I variant is a strong regulator of FSAP activity. A novel locus near ADCY2 was identified as a potential additional regulator of FSAP activity. Title: Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity.

2015年7月21日 · Results: We provide evidence that HABP2 is an important regulator of lung cancer progression. HABP2 expression was increased in several subtypes of patient non-small cell lung cancer samples. Further, HABP2 overexpression increased LMW-HA-induced uPA activation, migration, and extravasation in human lung adenocarcinoma cells.

2024年3月1日 · Clinical resource with information about HABP2, Thrombophilia due to thrombin defect, Thyroid cancer, nonmedullary, 5, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2015年12月8日 · By screening a human liver cDNA library using degenerate oligonucleotides based on the HABP2 amino acid sequence, they cloned HABP2. The deduced full-length 560-amino acid protein contains a signal peptide, 3 EGF domains, a kringle domain, and a serine protease domain. HABP2 has a calculated molecular mass of about 63 kD.

2015年7月20日 · Results: We provide evidence that HABP2 is an important regulator of lung cancer progression. HABP2 expression was increased in several subtypes of patient non-small cell lung cancer samples. Further, HABP2 overexpression increased LMW-HA-induced uPA activation, migration, and extravasation in human lung adenocarcinoma cells.