2024年12月25日 · Complete information for HADHB gene (Protein Coding), Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta, including: function, proteins, disorders, pathways, orthologs, and expression.

Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA), an enzyme involved in fatty acid beta-oxidation (FAO), is overexpressed in high-grade lymphoma and is a predictor of poor prognosis in diffuse large B-cell lymphoma (DLBCL).

The HADHB gene provides instructions for making part of an enzyme complex called mitochondrial trifunctional protein. Learn about this gene and related health conditions.

The expression level of HADHB is upregulated following metformin treatment in CRC cells. The authors suggest that the HADHB gene may regulate the functions of ATPase, basal transcription factor and the mitochondrion by mutations and/or structural changes.

Mitochondrial trifunctional protein deficiency is a rare condition that prevents the body from converting certain fats to energy, particularly during periods without food (fasting). Signs and symptoms of mitochondrial trifunctional protein deficiency may begin during infancy or later in life.

2025年2月24日 · After conducting RNA-sequencing (RNA-seq), we discovered that Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta (HADHB) was significantly downregulated in the highly invasive ccRCC cell line.

2022年4月1日 · Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA), an enzyme involved in fatty acid beta-oxidation (FAO), is overexpressed in high-grade lymphoma and is a predictor of poor prognosis in diffuse large B-cell lymphoma (DLBCL).

Mutations in the HADHB gene lead to Mitochondrial Trifunctional Protein (MTP) deficiency. MTP deficiency is a rare autosomal recessive disorder affecting long-chain fatty acid oxidation. Patients affected by MTP deficiency are unable to metabolize long-chain fatty-acids and suffer a …

HADHB, a fatty acid beta-oxidation enzyme, is a potential prognostic predictor in malignant lymphoma. MTP deficiency caused by HADHB mutations: Pathophysiology and clinical manifestations. Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex.

2024年3月5日 · Clinical resource with information about HADHB, Mitochondrial trifunctional protein deficiency 2, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.