关于 hagh Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,807,629-1,827,194 (from NCBI) This gene has 12 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 1 phenotype.

2024年12月25日 · HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. Diseases associated with HAGH include Hydroxyacyl Glutathione Hydrolase Deficiency and Abdominal Obesity-Metabolic Syndrome 1. Among its related pathways are Regulation of pyruvate metabolism and Respiratory electron transport.

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene. [ 5 ] [ 6 ] [ 7 ] The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.

hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II; Overexpression of glyoxalase II is associated with kidney tumor

2024年11月4日 · Title: CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers. Down regulation of Glyoxalase II was observed in cases of diabetic retinopathy as compared to controls.

In this paper, we demonstrate that extended transcripts from the human HAGH gene encode both cytosolic and mitochondrial isoforms of glyoxalase II, and that the previous mRNA sequence is incomplete. The cytosolic form originates by internal priming of protein synthesis from the initiating AUG codon previously identified in exon 1 ( 5 ).

Bioinformatic analysis revealed that the MR-1 gene is homologous to the hydroxyacylglutathione hydrolase (HAGH) gene. HAGH plays a role in a pathway to detoxify methylglyoxal, a compound present in coffee and alcoholic beverages and produced as a by-product of oxidative stress.

HAGH的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的酶被分类为thiolesterase并负责S-乳酰谷胱甘肽的水解还原的谷胱甘肽和D-乳酸。

2024年12月25日 · HAGHL (Hydroxyacylglutathione Hydrolase Like) is a Protein Coding gene. Diseases associated with HAGHL include Glycogen Storage Disease Ixc and Congenital Myopathy 4A, Autosomal Dominant.Gene Ontology (GO) annotations related to this gene include hydrolase activity and hydroxyacylglutathione hydrolase activity.An important paralog of …

预测在甲基乙二醛代谢过程的上游或s-乳酰谷胱甘肽内发挥作用，最终生成d-乳酸。位于线粒体中。在几个结构中表达，包括消化系统；大脑；生殖泌尿系统；呼吸系统；和感觉器官。与人类的hagh（羟基酰谷胱甘肽水解酶）正同源。