Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment. [1]

The hair cell is a flask-shaped epithelial cell named for the bundle of hairlike processes that protrude from its apical end into the scala media. Each hair bundle contains anywhere from 30 to a few hundred hexagonally arranged stereocilia , with one taller kinocilium ( Figure 13.7A ).

Hair cells are the transducers that change mechanical energy of motion to electrical signals conveyed as vestibular nerve action potentials. These hair cells come in two shapes, a goblet-shaped type I cell and a thinner, more columnar type II cell (Fig. 8.4A). Both of these cells contact the peripheral terminals of vestibular sensory axons ...

Be able to explain how sound transduction happens from inner hair cells to the brainstem. Be able to describe the motile response (electromotility) of the outer hair cells.

2018年6月18日 · Sensory hair cells are highly specialized mechanosensitive cells found in all vertebrate animals in some related chordates (tunicates). The structure of hair cells makes them highly sensitive to displacement of the fluid environment that surrounds their apical microvilli, or …

The cochlear hair cells in humans consist of one row of inner hair cells and three rows of outer hair cells (see Figure 13.4). The inner hair cells are the actual sensory receptors, and 95% of the fibers of the auditory nerve that project to the brain arise from this subpopulation.

2022年5月13日 · Sensory hair cells are exquisitely sensitive vertebrate mechanoreceptors that mediate the senses of hearing and balance. Understanding the factors that regulate the development of these cells is important, not only for our understanding of ear ...

Because mammalian hair cells do not regenerate, the repair of hair cell damage is important for continued auditory function throughout life. Here we discuss how several key hair cell structures can be damaged, and what is known about how they are repaired.

In the inner ear, the deflection of hair bundles, the sensory organelles of hair cells, activates mechanically-gated channels (MGCs). Hair bundles monitor the head’s orientation, its angular and linear acceleration, and detect sound.

2023年4月19日 · Regenerating hair cells through gene therapy approach. Studies like Chen’s show the promise of gene therapy for treating incurable conditions like hearing loss. Last year, this research project was selected out of hundreds as one of the Disruptive Dozen gene and cell therapy technologies most likely to have a significant impact on health care ...