Functional Diversity of Haloacid Dehalogenase Superfamily …
2015年7月24日 · The haloacid dehalogenase (HAD)-like enzymes comprise a large superfamily of phosphohydrolases present in all organisms. The Saccharomyces cerevisiae genome encodes at least 19 soluble HADs, including 10 uncharacterized proteins.
haloacid dehalogenase (HAD)2-like hydrolases, which repre-sent one of the largest enzyme superfamilies found in all organisms, with 479,051 sequences in databases (InterPro IPR023214) and 33 major families (24, 25). Most genomes are predicted to contain multiple HAD-like proteins, including 28 genes in E.coli, 45 genes in S.cerevisiae, and 183 ...
Insights into the functional divergence of the haloacid dehalogenase ...
2021年7月15日 · The evolution of enzyme catalytic structures and mechanisms has drawn increasing attention. In this study, we investigate the functional divergence from phosphomonoesterase to inorganic pyrophosphatase in the …
MDP-1 Is a New and Distinct Member of the Haloacid Dehalogenase …
2001年9月27日 · The presence of a conserved motif (Asp-X-Asp-X-Thr) in the N terminus of MDP-1 suggested a relationship to the haloacid dehalogenase (HAD) superfamily, which contains a number of magnesium-dependent acid phosphatases.
(PDF) Functional Diversity of Haloacid Dehalogenase Superfamily ...
2015年6月12日 · The haloacid dehalogenase (HAD)-like enzymes comprise a large superfamily of phosphohydrolases present in all organisms.
Characterization of haloacid dehalogenase superfamily acid …
2024年3月1日 · The haloacid dehalogenase superfamily proteins play a significant role in the pathogenicity of certain bacteria, facilitating invasion, survival, and proliferation within host cells. The genome of S. lugdunensis encodes more than ten proteins belonging to this superfamily.
Unraveling the mechanism: How does β-phosphoglucomutase …
2024年12月4日 · Evolutionary analysis of catalytic structure and function of haloacid dehalogenases. Identification of key residues that enhancing catalytic efficiency. Unraveling the mechanism behind β-phosphoglucomutase activity emergence.
Chronophin, a novel HAD-type serine protein phosphatase
2004年12月5日 · We report the biochemical isolation of chronophin (CIN), a unique cofilin-activating phosphatase of the haloacid dehalogenase (HAD) superfamily.
Dehalogenases: From Improved Performance to Potential …
2018年5月7日 · Haloacid dehalogenase (HAD)-like enzymes comprise a large superfamily of phosphohydrolases present in all organisms. The 2-haloacid dehalogenases are further classified into three types based on their substrate specificities.
X-ray Crystal Structure of the Hypothetical Phosphotyrosine …
2004年9月14日 · The haloacid dehalogenase (HAD) superfamily is comprised of structurally homologous enzymes that share several conserved sequence motifs (loops I−IV) in their active site. The majority of HAD members are phosphohydrolases and may be divided into three subclasses depending on domain organization.