HRCT findings not only help in the diagnosis of ABPA but can also predict outcome. HAM is a pathognomonic sign of ABPA. ABPA should be classified based on HRCT findings as ABPA-S, ABPA-CB and ABPA-CB-HAM as the presence of HAM at diagnosis represents immunologically severe disease and identifies patients at risk for recurrent relapses. Footnotes

2024年9月29日 · ABPA was first described by K F W Hinson et al in 1952 15. Differential diagnosis. For a discussion of the differential diagnosis of bronchiectasis please refer to the article bronchiectasis and more specifically central bronchiectasis. For mucoid impaction consider: mucoid impaction secondary to bronchiectasis. secondary to an endobronchial lesion

Radiologically, it presents with central bronchiectasis and recurrent episodes of mucus plugging. The mucus plugs in ABPA are generally hypodense but in up to 20% of patients, the mucus can be hyperdense on computed tomography. We report a case of high attenuation mucus (HAM) in a patient with acute exacerbation of asthma.

The new classification includes five classes: ABPA-S, ABPA-B, ABPA with mucus plugging (ABPA-MP), ABPA-HAM and ABPA-CPF . ABPA-S refers to patients of ABPA without bronchiectasis, while ABPA-B includes patients with bronchiectasis. ABPA-HAM has been retained, as HAM is an independent and pathognomonic diagnostic feature of ABPA . …

Based on the presence or absence of HAM it should be graded as ABPA-S (mild), ABPA-CB (moderate), and ABPA-CB-HAM (severe). Our study showed that HRCT chest may be normal in patients with ABPA which categorizes them into ABPA-S. Central bronchiectasis which is a radiologically characteristic feature of ABPA was seen in 78% patients which were ...

abpa-ham组较abpa-b组及abpa-s组患者第1秒用力呼气容积占预计值百分比下降明显，受累的肺段明显增多(p值均<0.05)。 结论 ABPA-HAM组患者病情更加严重，外周血嗜酸粒细胞计数、血清总IgE和曲霉特异性IgE水平更高，第1秒用力呼气容积占预计值百分比下降明显。

2016年5月1日 · Recent studies have highlighted the significance of HAM in ABPA. 12, 13 HAM has been found to be an independent predictor of frequent relapses and baseline immunologic severity in ABPA. However, no study has correlated the mean CT density value of mucoid impaction with immunologic severity. In this context, the present study was performed to ...

2024年10月12日 · 近年来对变应性支气管肺曲霉病（abpa）的研究逐渐深入，检测方法日趋完善，国内外诊断标准也持续更新，2024年国际人类和动物真菌学会成立abpa工作组，采用改良的德尔菲法对abpa的诊断、分类、治疗进行了更新。新的指南有助于提高abpa的诊断敏感度，对abpa的不同分期给出了更加明确的定义，对 ...

2024年9月29日 · High-attenuation mucus (HAM) is a form of mucoid impaction which is often considered a characteristic and an "almost pathognomonic" feature of allergic bronchopulmonary aspergillosis (ABPA) (close to 100% specificity) 1. Epidemiology It may be ...

hamはabpaに特有な所見であるとされている 8）． abpaの粘液栓は，一般的には低吸収でhamを認める 症例は20％以下とされていたが2），2013年の喘息患者372 名を対象にした研究では，abpaに対するhamの感度 は39.7％，特異度は100％と報告されている9）．