A member of the HAND subclass of basic Helix-loop-helix (bHLH) transcription factors, the Heart and neural crest-derived transcript-1 (HAND1) gene is vital for the development and differentiation of three distinct embryological lineages including the cardiac muscle cells of the heart, trophoblast of the placenta, and yolk sac vasculogenesis. [8 ...

2024年12月25日 · HAND1 (Heart And Neural Crest Derivatives Expressed 1) is a Protein Coding gene. Diseases associated with HAND1 include Atrial Septal Defect 5 and Bladder Cancer. Among its related pathways are NFAT and Cardiac Hypertrophy and …

HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy. Combined expression of NKX2-5, HAND1, and NOTCH1 coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome. Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors.

Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein (s) are secreted or actually retained in intracellular locations or membrane-attached.

HAND1 is a bHLH transcription factor encoded by the gene HANDI, which has been associated with congenital heart diseases in humans (including ventricular septal defects and double outlet right ventricle) and impaired transcriptional function (Li et …

2007年9月23日 · We identify a novel interaction of Hand1 with a protein that contains an I-mfa (inhibitor of myogenic factor) domain that anchors Hand1 in the nucleolus where it negatively regulates Hand1...

General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene …

2006年11月15日 · Hand1 (previously known as eHAND, Hxt and Thing1), a member of the bHLH transcription factor family, is a candidate regulator of cardiac precursor cell fate.

Gene target information for HAND1 - heart and neural crest derivatives expressed 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

cardiovascular system are the first organ sys tems to form during m. mmalian embryogenesis. We show here that a single gene is critical for development of both. The Hand1 gene, previously called...