In molecular biology, Human Accelerated Region 1 (Highly Accelerated Region 1, HAR1) is a segment of the human genome found on the long arm of chromosome 20. It is a human accelerated region. It is located within a pair of overlapping long non-coding RNA genes, HAR1A (HAR1F) and HAR1B (HAR1R). [1]

HAR1 is a 106-base pair stretch found on the long arm of chromosome 20 overlapping with part of the RNA genes HAR1F and HAR1R. HAR1F is active in the developing human brain. The HAR1 sequence is found (and conserved) in chickens and chimpanzees but is not present in fish or frogs that have been studied.

2006年8月16日 · Here we report that the most dramatic of these ‘human accelerated regions’, HAR1, is part of a novel RNA gene (HAR1F) that is expressed specifically in Cajal–Retzius neurons in the developing...

2016年10月6日 · Human Accelerated Regions 1 (HAR1) is part of the cis-antisense RNA gene pair HAR1F and HAR1R, which are expressed in neurons during human embryonic cortical development and adult brain. HAR1 is conserved in amniotes as far back as frogs, but 18 base pair substitutions have occurred specifically in the human lineage leading to a secondary ...

2008年2月29日 · Human accelerated region 1 (HAR1) is a short DNA region identified recently to have evolved the most rapidly among highly constrained regions since the divergence from our common ancestor with chimpanzee. It is transcribed as part of a noncoding RNA specifically expressed in the developing human neocortex.

2006年8月17日 · Now a new computational technique has identified 49 regions that have changed particularly quickly between humans and chimps, and may have revealed at least one gene critical to the development...

Human accelerated regions (HARs) and human-specific genomic rearrangements, including deletions and segmental duplications, are among the most interesting sequences in the human genome to study, because they seem to shed light on the appearance of Homo sapiens as a species, especially in the sense of the exceptionally developed human brain (O’Bl...

Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study. Keywords: DNA conservation; HAR1; genetic evolution; lncRNAs; molecular structure.

2006年8月16日 · In a computer-based search for pieces of DNA that have undergone the most change since the ancestors of humans and chimps diverged, "Human Accelerated Region 1" or HAR1, was a clear standout, said lead author Katie Pollard, assistant professor at the UC Davis Genome Center and the Department of Statistics.

2002年11月6日 · Here we report impaired systemic regulation by har1 mutants and molecular identification of the HAR1 gene. We used grafts involving Gifu B-129 (wild type) and the har1-5 mutant line to...