Harmine is a beta-carboline and a harmala alkaloid. It occurs in a number of different plants, most notably the Syrian rue and Banisteriopsis caapi. [3] Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a Reversible inhibitor of monoamine oxidase A (RIMA). Harmine does not inhibit MAO-B. [4]

Harmine 是一种具有抗癌和抗炎活性的天然双特异性酪氨酸磷酸化调节激酶 (DYRK) 抑制剂。Harmine 对 5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。- 高纯度，全球文献引用。

Harmine is a highly potent inhibitor of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK). Harmine has been reported to have antidepressant-like actions in rodents. Harmine possesses anxiolytic, behavioral effects and anti-tumor potential both in vitro and in vivo.

Harmine is a beta-carboline alkaloid well-known for giving Ayahuasca its hallucinogenic effects. Its main sources are the wild plants Peganum harmala (Syrian rue) and Banisteriopsis caapi, which are noted for their therapeutic value.

Harmine is a harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7. It has a role as a metabolite, an anti-HIV agent and an EC 1.4.3.4 (monoamine oxidase) inhibitor. It derives from a hydride of a harman.

2021年3月30日 · Our data suggest that harmine is a promising therapeutic agent for cardiac hypertrophy independent of blood pressure modulation and could be a promising addition of current medications for...

Harmine, hallucinogenic alkaloid found in the seed coats of a plant (Peganum harmala) of the Mediterranean region and the Middle East, and also in a South American vine (Banisteriopsis caapi) from which natives of the Andes Mountains prepared a …

Harmine is a tricyclic alkaloid compound in the ß-carboline family. 1 It was originally isolated in 1847 from the seeds of the wild rue, Peganum harmala, but it is found throughout nature in mammals, insects, and marine organisms. Harmine was recently isolated from several species of psychedelic mushrooms. 2

2020年11月18日 · Harmine has many pharmacological activities including anti-inflammatory, neuroprotective, antidiabetic, and antitumor activities. Moreover, harmine exhibits insecticidal, antiviral, and antibacterial effects. Harmine derivatives exhibit pharmacological effects similar to those of harmine, but with better antitumor activity and low neurotoxicity.

2024年9月17日 · This review discusses the anticancer capabilities of harmine and its derivatives against malignancies such as breast cancer, lung cancer, gastric cancer, colon cancer, glioblastoma, neuroblastoma, liver cancer, pancreatic cancer and thyroid cancer. Harmine uses mechanisms such as apoptosis and angiogenesis inhibition to fight cancer cells.