HATK (HLA Analysis Tool-Kit) is a collection of tools and modules to perform HLA fine-mapping analysis, which is to identify which HLA allele or amino acid position of the HLA gene is driving the disease. HLA fine-mapping analysis is an indispensable analysis in …

2020年7月31日 · In this article, we introduce a novel software package, HLA Analysis Tool Kit (HATK), which helps in overcoming these obstacles (Fig. 1A). Our software takes the HLA alleles of samples as input, for which the output of various …

Using information regarding HLA alleles obtained from HLA typing, HLA imputation or HLA inference, our software expands the alleles to amino acid sequences using the most recent IMGT/HLA database and prepares a dataset suitable for fine-mapping analysis.

2021年4月20日 · Using information regarding HLA alleles obtained from HLA typing, HLA imputation or HLA inference, our software expands the alleles to amino acid sequences using the most recent IMGT/HLA database and prepares a dataset suitable for fine-mapping analysis.

使用从 HLA 分型、HLA 插补或 HLA 推断获得的有关 HLA 等位基因的信息，我们的软件使用最新的 IMGT/HLA 数据库将等位基因扩展为氨基酸序列，并准备适合精细定位分析的数据集。 我们的软件还提供有用的功能，例如各种关联测试、可视化工具和术语转换。 HATK: HLA Analysis Toolkit. Fine-mapping human leukocyte antigen (HLA) genes involved in disease susceptibility to individual alleles or amino acid residues has been challenging.

A collection of modules to process and analyze IMGT-HLA sequences. - WansonChoi/HATK

2021年4月20日 · Using information regarding HLA alleles obtained from HLA typing, HLA imputation or HLA inference, our software expands the alleles to amino acid sequences using the most recent IMGT/HLA database and prepares a dataset suitable for fine-mapping analysis.

2020年7月31日 · Using information regarding HLA alleles obtained from HLA typing, HLA imputation, or HLA inference, our software expands the alleles to amino acid sequences using the most recent IMGT/HLA database,...

HATK (HLA Analysis Tool-Kit) is a collection of tools and modules to perform HLA fine-mapping analysis, which is to identify which HLA allele or amino acid position of the HLA gene is driving the disease. HLA fine-mapping analysis is an indispensable analysis in …

通过hatk，研究人员可以将hla序列数据与gwas数据相结合，使用专门的统计方法对数据进行精细映射，从而减少信号丢失，并提高与hla相关的变异检测的准确性。