Testing for the beta-thalassemia trait is usually identified when the value of HbA2 is higher than 3.5%. [3] . HbA2 is also important for diagnosing sickle cell disease, which is one of the most prevalent genetic conditions.

What is HbA2 Haemoglobin A2 Test? Haemoglobin is the substance in the blood which carries oxygen (air) around the body and makes the blood look red in colour. Every unborn baby produces a minor adult type haemoglobin called Hemoglobin A2; this haemoglobin is produced irrespective of the type of major adult haemoglobin they have inherited from ...

Investigate for hemolytic anemia, hemoglobinopathies, and thalassemia. Specify on the request form the patient's race or ethnic origin (if known) as well as the date of any transfusions administered within the preceding three months. Capillary electrophoresis (CE) …

Elevated levels of Hemoglobin A2 (HbA2) in a blood test can indicate certain health conditions, most notably beta thalassemia, a blood disorder. Hemoglobin is a protein in your red blood cells that carries oxygen throughout your body.

Hemoglobin electrophoresis is used as a screening test to identify variant and abnormal hemoglobins, including hemoglobin A1 (HbA1), hemoglobin A2 (HbA2), hemoglobin...

Quantitative HbA2 determination is the most valuable test for β-thalassaemia carrier identification. Several methods have been set up, but only a few are now recommended for their accuracy. It should be pointed out that the precision and accuracy of HbA2 determination using densitometry scanning after cellulose acetate electrophoresis is ...

HBA2. Epic Name. Hemoglobin A2 Quant. Description. Hb A2 is eluted from the column resin by a programmed buffer gradient of increasing ionic strength. Hb A2 measurement is best interpreted in conjunction with other testing in the Thalassemia Reflexive Panel and red cell indices and iron supply measurements. Synonyms. HbA2, Hb A2

Results: The normal ranges for HbA2 and HbF by CE were 2.75% (SD 0.26%) and 0.03% (SD 0.24%) respectively, which were significantly lower than that of HPLC 2.88% (SD 0.25%) and 0.58% (SD 0.61%) (p < 0.001). The HbA2 level for HbE heterozygotes was 3.58% (SD 0.44%), which was significantly higher than normal (p < 0.001) but lower than that of ...

Forms part of the haemoglobinopathy screen (see Haemoglobin electrophoresis) for the investigation of thalassaemia and haemoglobinopathies. HbA 2 is usually raised in the beta thalassaemia (with a mild microcytic anaemia), and in unstable haemoglobinopathies where the amino acid substitution is on the beta chain.

Preferred first-tier genetic test for confirmation of suspected alpha thalassemia or alpha thalassemia trait. Use to detect common as well as rare and novel deletions or duplications of the alpha globin gene cluster and the hemoglobin Constant Spring (HbCS) variant. ||Transport 2 …