Hemoglobin E trait is an inherited blood disorder. That means it is passed down through your parent’s genes. It leads to an abnormal form of hemoglobin that may cause mild anemia. It occurs most often in people of Southeast Asian descent. What causes hemoglobin E trait? Hemoglobin E trait is caused by a gene defect.

People who have hemoglobin E trait (heterozygous) are asymptomatic and their state does not usually result in health problems. They may have a low mean corpuscular volume (MCV) and very abnormal red blood cells (target cells), but clinical relevance is mainly due to the potential for transmitting E or β-thalassemia. [4]

Hemoglobin E trait is a condition that affects the red blood cells. Your red blood cells contain hemoglobin, which carries oxygen from the lungs to all parts of your body.

Hemoglobin E (HbE) is a common structural β-hemoglobin variant. Although HbE alone does not cause significant clinical problems, its interactions with other thalassemias produce syndromes of varying severity. As discussed by Williams and Weatherall (2012), HbE occurs at an extremely high frequency in many countries in Asia.

Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) is the genotype responsible for approximately one-half of all severe beta-thalassaemia worldwide. The disorder is characterized by marked clinical variability, ranging from a mild and asymptomatic anaemia to a life-threatening disorder requiring transfusions from infancy.

2007年1月1日 · Hemoglobin (Hb) E is one of the world’s most common and important mutations. It results in a heterogeneous group of disorders whose phenotype range from asymptomatic to severe. Hb E trait and Hb EE are mild disorders. The combination of Hb E and Hb S (Hb SE) results in a sickle cell disease syndrome similar to sickle β + thalassemia. It is ...

Hemoglobin E (HbE) disease is a mild, inherited blood disorder characterized by an abnormal form of hemoglobin, called hemoglobin E. People with this condition may have very mild anemia, but the condition typically does not cause any symptoms.

Key points about hemoglobin E trait. Hemoglobin E trait is inherited or passed down from parents to children, like hair color or eye color. Hemoglobin E trait is most common in people of Southeast Asian descent. People with hemoglobin E trait have both normal hemoglobin A and abnormal hemoglobin E in their red blood cells.

What is hemoglobin E trait? Hemoglobin E trait (AE) is an inherited condition which affects the hemoglobin in your red blood cells. • Hemoglobin is a protein in red blood cells. The job of hemoglobin is to carry oxygen through the body. • Each person inherits two hemoglobin genes – one from each parent.

HbE Trait. HbE heterozygotes are clinically normal, with minimal changes in blood counts and erythrocyte indices. Red cell morphology is similar to that in thalassaemia minor with normocytic or slightly microcytic red cells (MCV 84±5fl). A few target cells may be present in the blood smear.