HCK comprises five distinct domains which include two terminal domains and three SH domains. The N-terminal domain is important for lipid modifications and a C-terminal domain includes a …

The hematopoietic cell kinase (HCK) is a member of the SRC family of cytoplasmic tyrosine kinases (SFKs), and is expressed in cells of the myeloid and B-lymphocyte cell lineages. …

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Dec 25, 2024 · HCK (HCK Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with HCK include Autoinflammation With Pulmonary And …

Jul 18, 2023 · HCK-knockout (KO) or HCK-inhibitor decreases macrophage M1-like pro-inflammatory polarization, proliferation, and migration in RAW264.7 cells and bone marrow …

Hck regulates the expression of mannose receptor, CD36, and MAO-A in alternatively activated monocytes by IL-13.

Phosphorylation by the BCR-ABL fusion protein mediates activation of HCK. Phosphorylation at Tyr-411 increases kinase activity. Phosphorylation at Tyr-522 inhibits kinase activity.

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Apr 1, 2023 · Hck is a critical gene that promotes the different polarization phenotypes of macrophages, and macrophages of different polarization types secrete other cytokines such …

Mar 24, 2023 · HCK is an SRC family tyrosine kinase that is expressed predominantly in granulocytic and monocytic cells. It has proposed functional roles in phagocytosis and receptor …