2025年1月22日 · Hemolytic disease of the fetus and newborn (HDFN), also known as erythroblastosis fetalis, is a complex and potentially life-threatening condition arising from maternal-fetal blood group incompatibility.

IgG抗体的孕妇血浆测定IgG 亚型的含量, 可预测HDFN的发生概率及严重程度。常用检测方法包括传统的酶联免疫吸附(ELISA) 试验和流式细胞术,可定量分析孕妇血清中IgG 抗体各亚型的浓度; 另外,新型微柱凝胶技术是将抗原抗体特异性反应、生化凝胶过滤分子筛技术 ...

Hemolytic disease of the fetus and newborn (HDFN) is characterized by the presence of IgG antibodies in the maternal circulation, directed against a paternally derived antigen present in the fetal/neonatal red cells that cause hemolysis in the fetus by crossing the placenta and sensitizing red cells for destruction by the macrophages in the ...

Using structured (diagnostic/procedural codes, medication, and laboratory records) and unstructured (clinical notes analyzed via natural language processing) data abstracted from EHRs, we extracted HDFN-specific "indicators" (maternal positive antibody test and abnormal antibody titer, maternal/infant HDFN diagnosis and blood transfusion ...

2015年12月5日 · Hemolytic disease of the fetus and newborn (HDFN) is rare condition that occurs when maternal red blood cell (RBC) or blood group antibodies cross the placenta during pregnancy and cause fetal red cell destruction. The fetal physiological consequences of severe anemia in the fetus can also lead to edema, ascites, hydrops, heart failure, and death.

2025年1月14日 · 胎儿及新生儿溶血病（HDFN）是由母体IgG抗体破坏胎儿红细胞引起的血液疾病，可导致胎儿贫血、水肿胎及围产期死亡。 尽管针对妊娠相关同种免疫的预防措施已显著减少HDFN的发病率，但其产后管理方式和结局仍存在国际间较大差异。

Laboratory monitoring of mother, fetus, and newborn in hemolytic disease of fetus and newborn (HDFN) aims to guide clinicians and the immunized women to focus on the most serious problems of alloimmunization and thus minimize the consequences …

Haemolytic disease of the foetus and newborn (HDFN) is most commonly due to red cell alloimmunisation. In HDFN, maternal immunoglobulin antibodies directed against foetal red blood cells pass through the placenta into the foetal circulation and cause the destruction of …

2025年1月10日 · A study of management of HDFN in LMICs would provide a clearer baseline to work from for consensus building and impact. We appreciate the effort by the authors to start to characterize current practice patterns and set the foundation for optimization.

2022年9月1日 · Hemolytic disease of the fetus and newborn (HDFN) is a rare condition that maternal antibodies cross the placenta and cause fetal red cell destruction, lead to fetal edema, ascites, hydrops, and even death [1].