Here’s how normal cardiac metabolism works: adenosine triphosphate (ATP) is the primary energy source for the heart and is used to fuel the heart’s activities – 60-70% of ATP is used to fuel the contraction of the heart muscle, and the remaining 30-40% is used in ion pumps.

2021年5月14日 · Any disruptions in the energy metabolic pathways that produce ATP, or in oxygen supply to the heart, can have catastrophic consequences on cardiac function. As a result, compromised energy production by the heart is an important contributor to …

Characterizing cardiac metabolism in heart failure revealed several metabolic alterations termed metabolic remodeling, ranging from changes in substrate utilization to mitochondrial dysfunction, ultimately resulting in ATP deficiency and impaired contractility.

2023年5月26日 · Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has been...

2024年12月11日 · Generally, patients with heart failure have decreased ATP production in cardiac myocytes as well as other abnormalities in cardiac metabolism, including cell death. 4,13 The electron transport chain and phosphorylation apparatus is now thought to be where the mitochondrial defects are found.

ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases.

2009年12月4日 · The human heart contains approximately 700 mg of ATP, enough to fuel one heartbeat per second for ten seconds, and needs a minimum of 6,000 grams of ATP per day to function. As the universal cellular energy currency, ATP …

Figure 1.1 is a cartoon summarizing the story of ATP and the Heart. On the right are the primary ATP utilizing reactions: myosin ATPase in the myofibril, the Ca2+-ATPase in the sarcoplasmic reticulum and the Nat, K+-ATPase in the sarcolemma.

The very high energy demand of the heart is primarily met by adenosine triphosphate (ATP) production from mitochondrial oxidative phosphorylation, with glycolysis providing a smaller amount of ATP production. This ATP production is markedly altered ...

2024年7月2日 · The levels of ATP and free ADP (<20 μM, i.e., >100× less than ATP; note that up to 90% of ADP is bound to actin filaments) are defended by the heart to maintain constant the ΔG of ATP hydrolysis at ∼60 kJ/mol, the driving force for cardiac work. On average, each cardiac stroke generates ∼1 J of work, costing ∼100 μmol ATP.