Cardiac fibroblasts are the major heart cells producing COL1 and COL3. Fibrillar collagen is initially synthetized as a procollagen, which is then split by specific proteinases into carboxy …

COL1 degradation markers seem to be more relevant in ischemic heart disease including atherosclerosis and acute MI. The REVE-2 study in MI patients with low PIIINP (a marker of …

In summary, we review human-specific quantitative measurements of major structural ECM proteins (COL1, COL3, and ELN) in the heart and aorta. We determine how the COL1/COL3 …

越来越多的证据表明，两种主要蛋白质负责结合心肌细胞的结构一致性。这些生物分子被称为心肌纤维胶原 i 型 (col1) 和 iii 型 (col3)。此外，纤连蛋白、层粘连蛋白、原纤维蛋白、弹性蛋白、 …

2024年3月22日 · In vitro experiments showed that the suppression of HTRA1 inhibited the conversion of cardiac fibroblasts into myofibroblasts and decreased Col1 secretion. Further …

2022年2月20日 · Accumulating evidence indicates that two major proteins are responsible for the structural coherence of bounding cardiomyocytes. These biomolecules are known as …

2025年3月5日 · Collagen type I (COL1) is the most abundant protein in the human body and is a main component in the extracellular matrix. The COL1 structure vastly influences normal …

2022年3月28日 · Accumulating evidence indicates that two major proteins are responsible for the structural coherence of bounding cardiomyocytes. These biomolecules are known as …

2024年11月11日 · Type-I collagen (COL1) is the main constituent of the myocardium, and its’ degradation could result in destabilisation of the cardiac tissue and increase the risk of …

2024年3月22日 · I型胶原(Col1)的异常分泌和过度沉积是扩张型心肌病(DCM)心肌纤维化发病机制的重要因素。 然而，Col1 合成和分泌的精确分子机制仍不清楚。 RNA 测序分析显示 DCM 患 …