The 293A Cell Line is a subclone of the 293 Cell Line and has a relatively flat morphology. It facilitates the initial production, amplification and titering of replication-incompetent adenovirus. The cell line contains a stably integrated copy of the E1 gene that supplies the E1 proteins (E1a and E1b) required to generate recombinant adenovirus.

Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, are an immortalised cell line derived from HEK cells isolated from a female fetus in the 1970s. [1][2] The HEK 293 cell line has been widely used in research for decades due to its reliable and fast growth and propensity for transfection.

293 [HEK-293] is a cell line exhibiting epithelial morphology that was isolated from the kidney of a human embryo. This cell line can be used in industrial biotechnology and toxicology research. It has applications in efficacy testing and viruscide testing.

The scattered twelve tribes of HEK293. Biomed. Pharmacol. J. 11:621-623 (2018)

2022年5月20日 · HEK-293人胚肾细胞：是用5型腺病毒75株系转化，含有Ad5 E1区的人胚肾亚三倍体细胞系，是一种E1区缺陷互补细胞系。 它是加拿大McMaster University 的F.L.Graham与J.S.Miley于1976年用DNA转染技术构建而成。 该细胞为人类腺病毒载体扩增的宿主。 可表达异常的玻连蛋白的细胞表面受体，由整合素β1亚单位和玻连蛋白受体α-v亚单位组成。 HEK-293T …

The 293A Cell Line is a subclone of the 293 Cell Line and has a relatively flat morphology. The 293 Cell Line is a permanent line established from primary embryonal human kidney transformed with sheared human adenovirus type 5 DNA.

Among the human cell lines, HEK293 is widely utilized due to its high transfectivity, rapid growth rate, and ability to grow in a serum-free, suspension culture. In this review, we discuss the use of HEK293 cells and its subtypes in the production of biotherapeutics.

The HEK293 cell line is a permanent line established from primary embryonic human kidney, which was transformed with sheared human adenovirus type 5 DNA. The adenoviral genes expressed in this cell line allow the cells to produce very high levels of recombinant proteins.

Until two decades ago, the HEK293 cell line was mainly used for transient, small to medium-scale production of research-grade proteins for scientific and pre-clinical studies. Its desirable characteristics have propelled this cell line into a potential producer of biopharmaceuticals [11, …

2024年11月12日 · HEK293H cells are derived from HEK293 cells expressing the E1A gene of adenovirus. These cells have strong adhesion properties and are commonly used in plaque assays and for recombinant protein expression and production. Insertion of the EBNA-1 gene into HEK293H cells results in the creation of 293E cells.