Structural analysis of heme proteins: implications for design and ...
2011年3月3日 · The first concerns the structural implications of the heme-interactive sequence motifs. CXXCH represents the classic type-c heme binding motif in which the two vinyl groups …
Shapes and Patterns of Heme-Binding Motifs in Mammalian Heme …
2023年6月23日 · In this report, we focus on the evaluation of known mammalian heme-regulated proteins concerning specific recognition and structural patterns in their HBMs. The Cys-Pro …
Regulation of protein function and degradation by heme, heme …
In this review, we focus on how heme binding to heme regulatory motifs (HRMs), catalytic sites, and gas signaling molecules as well as how changes in the heme redox state regulate protein …
The heme-regulatory motifs of heme oxygenase-2 contribute to …
Heme-regulatory motifs (HRMs) are present in many proteins that are involved in diverse biological functions. The C-terminal tail region of human heme oxygenase-2 (HO2) contains …
A novel heme-regulatory motif mediates heme-dependent
We identify heme, an iron-containing prosthetic group, as a regulatory ligand controlling human Period-2 (hPer2) stability. Furthermore, we define a novel heme-regulatory motif within the C …
Discovery of a functional, contracted heme-binding motif within a ...
2019年11月8日 · Here, we report the discovery of a functional tetraheme c -type cytochrome from the anammox bacterium Kuenenia stuttgartiensis with a naturally-occurring contracted …
Involvement of Heme Regulatory Motif in Heme-Mediated …
2005年7月22日 · Iron regulatory protein 2 (IRP2), a regulator of iron metabolism, is modulated by ubiquitination and degradation. We have shown that IRP2 degradation is triggered by heme …
Involvement of heme regulatory motif in heme-mediated
2005年7月22日 · Iron regulatory protein 2 (IRP2), a regulator of iron metabolism, is modulated by ubiquitination and degradation. We have shown that IRP2 degradation is triggered by heme …
Regulation of protein function and degradation by heme, heme
In this review, we focus on how heme binding to heme regulatory motifs (HRMs), catalytic sites, and gas signaling molecules as well as how changes in the heme redox state regulate protein …
Insights into the molecular basis and mechanism of heme…
2023年10月26日 · We report the interaction of TLR4, MD2 and the TLR4-MD2 complex with heme and the consequences thereof by employing biochemical, spectroscopic, bioinformatic …