Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. [1][2] In humans, they are encoded in the leukocyte receptor complex (LRC) on chromosome 19q13.4; the KIR region is approximately 150 kilobases and contains ...

2024年2月28日 · 杀伤细胞免疫球蛋白样受体（Killer Cell Immunoglobulin-like Receptors, KIR，即CD158）是一个由14个多态性基因编码的受体家族（KIR2DL1 、 2DL2 、 2DL3 、 2DL4 、2DL5； KIR3DL1 、 3DL2 、 3DL3； KIR2DS1 、 2DS2 、 2DS3 、 2DS4 、 …

2023年6月16日 · Killer immunoglobulin-like receptors (KIR) play an important role in NK cells after hematopoietic stem cell transplantation.

2019年5月27日 · Several strategies have been developed to analyze KIR repertoires, including approaches able to analyze P/A of the different KIR genes, KIR gene copy number variations, and, more recently, a “whole” KIR allele typing by next generation sequencing (NGS) approach (87, 90 – 100) underlining the huge interest of the immunologists in the KIR ...

Killer immunoglobulin-like receptors (KIR) regulate the function of natural killer cells through interactions with various ligands on the surface of cells, thereby determining whether natural killer (NK) cells are to be activated or inhibited from killing the cell being interrogated.

2004年12月16日 · A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). An interesting facet of the KIR family is the unusual variability of the respective gene cluster, which is changing …

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2020年12月1日 · We have recently shown a broad disparity of Natural Killer (NK) cell responses against leukemia, highlighting good and bad responders resting on the Killer cell Immunoglobulin-like Receptors (KIR) and HLA genetics.

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