Role of iron deficiency anemia in the propagation of beta …
2011年3月15日 · Eight patients, in which hemoglobin electrophoresis had failed to diagnose BTT, were found with a co-pathological condition, i.e., BTT with IDA, as they have low levels of serum ferritin (Table 2). The 10 microcytic hypochromic anemic patients were diagnosed as IDA based on peripheral blood morphology and low levels of serum ferritin.
Evaluation of Microcytosis - AAFP
2010年11月1日 · Hemoglobin electrophoresis may be considered earlier in the evaluation of children and young adults with microcytosis, in whom beta-thalassemia trait is more common. In the United States, the...
Investigation of iron deficiency anaemia - PMC - PubMed Central …
Iron deficiency anaemia (IDA) is an important, common clinical condition and 8–15% of these patients will be diagnosed with a gastrointestinal cancer. IDA is defined as haemoglobin below the lower limit of normal, in the presence of characteristic ...
Influence of iron deficiency anaemia on haemoglobin A2 levels ... - PubMed
Iron deficiency modulates the synthesis of HbA2, resulting in reduced HbA2 levels in patients with iron deficiency anaemia. The diagnosis heterozygous beta-thalassaemia is based on a raised HbA2 level. Patients with beta-thalassaemia and concomitant iron …
Hemoglobin E Syndromes - American Society of Hematology
2007年1月1日 · Hemoglobin (Hb) E is one of the world’s most common and important mutations. It results in a heterogeneous group of disorders whose phenotype range from asymptomatic to severe. Hb E trait and Hb EE are mild disorders. The combination of Hb E and Hb S (Hb SE) results in a sickle cell disease syndrome similar to sickle β + thalassemia.
Hb E trait: microcytosis (mean MCV=65fl). No anemia. The test examines the complete beta globin coding sequence, the splice sites and other intronic regions known to harbor mutations, the proximal promoter region, and the 5’ and 3’UTR regions. Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Prchal J, Seligsohn U. Willam’s Hematology.
Hemoglobin Electrophoresis - Medscape
2019年11月20日 · Hemoglobin electrophoresis is used as a screening test to identify variant and abnormal hemoglobins, including hemoglobin A1 (HbA1), hemoglobin A2 (HbA2), hemoglobin F (HbF; fetal hemoglobin),...
Differential Diagnosis of Iron-Deficiency Anemia from β …
Iron deficiency anemia (IDA) and β-thalassemia trait (β-TT) are the most common types of microcytic hypochromic anemias. The similarity and the nature of anemia-related symptoms pose a foremost challenge for discriminating between IDA and β-TT. Currently, advances in technology have gave rise to computer-based decision-making systems.
Iron deficiency anemia interfering the diagnosis of compound ...
2017年2月28日 · We report a challenging diagnosis of compound heterozygosity for Hb Constant Spring (HbCS) and Hb Paksé in a patient with iron deficiency anemia. A 43‐year‐old Thai female, originating from the northeastern part of Thailand, was referred to hematology clinic to evaluate the causes of severe microcytic anemia at King Chulalongkorn Memorial Hospital.
The effect of Iron Deficiency Anemia (IDA) on the HbA2 level and ...
2006年11月30日 · Our aim in this study was evaluating the effect of IDA on HbA<sub>2</sub> levels; Furthermore hematolagic values in CBC of these two diseases will be compared. In this study 291 individuals...