Hemophagocytic lymphohistiocytosis is a rare and often life-threatening condition if left untreated. HLH causes your immune system to attack your body instead of a foreign invader like a virus. The condition is either acquired or genetic and there’s no way to prevent it. Treatment is available and most effective with an early diagnosis.

Hemophagocytic lymphohistiocytosis (HLH) is a rare disease that usually occurs in infants and young children. It may also occur in adults. Children usually inherit the disease. In adults, many different conditions, including infections and cancer, can cause HLH.

It is a life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of benign lymphocytes and macrophages that secrete high amounts of inflammatory cytokines. It is classified as one of the cytokine storm syndromes. There are inherited and non-inherited (acquired) causes of HLH.

噬血细胞综合征 （hemophagocytic syndrome, HPS）又称噬血细胞性淋巴组织细胞增生症（hemophagocytic lymphohistiocytosis, HLH ），是一组由多种病因诱发细胞因子“瀑布”释放，组织病理学检查可见组织细胞增生伴吞噬各种造血细胞为特征的临床综合征。其临床特点是持续 ...

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. HLH most often affects infants from birth to 18 months of age, but it also occurs in children and adults of all ages.

2025年2月5日 · Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening syndrome characterized by overwhelming inflammation that often leads to multiorgan failure and death if not treated...

2023年3月27日 · Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyper-inflammatory disorder that affects newborns and adults alike. The disease is characterized by dysregulated immune activity that results in malignant inflammation and multi-organ failure.

2019年6月6日 · Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) form, caused by mutations affecting lymphocyte cytotoxicity and immune regulation, is most common in children, whereas the secondary (acquired) form is most frequent in adults.

2018年12月13日 · Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition caused by an overactive, abnormal response of the immune system. The immune system is the body’s natural defense system against foreign or invading organisms or substances.

Hemophagocytic syndromes (hemophagocytic lymphohistiocytosis, HLH) represent a severe hyperinflammatory condition with the cardinal symptoms prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. Biochemical markers include elevated fe …