Oct 13, 2022 · Hemophagocytic lymphohistiocytosis (HLH) is a condition that occurs when your immune system abnormally overreacts. Your immune system defends your body from things that make you sick, like bacteria and viruses.

Hemophagocytic lymphohistiocytosis (HLH) is a rare disease that usually occurs in infants and young children. It may also occur in adults. Children usually inherit the disease. In adults, many different conditions, including infections and cancer, can cause HLH.

Primary HLH, also known as familial haemophagocytic lymphohistiocytosis (FHL) or familial erythrophagocytic lymphohistiocytosis, is a heterogeneous autosomal recessive disorder found to be more prevalent with parental consanguinity.

Jun 6, 2019 · Hemophagocytic lymphohistiocytosis (HLH) has become more widely recognized in adults, with all ages affected. Patients often suffer from recurrent fever, cytopenia, liver dysfunction, and a sepsis-like syndrome that may rapidly progress to …

Jun 5, 2024 · HLH causes a hemorrhagic form of DIC with increased risk of bleeding due to low fibrinogen levels. Prior to lumbar puncture, consider checking a fibrinogen level, coagulation studies, and complete blood count. Basic chemistry findings may include elevated protein levels and lymphocytic pleocytosis.

Hemophagocytic lymphohistiocytosis (HLH) is rare life-threatening syndrome that can affect infants, children, adolescents and adults. HLH is not a single disease, however; it is a group of disorders of the immune system that can be triggered by infections, cancer or …

Mar 27, 2023 · Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyper-inflammatory disorder affecting both newborns and adults alike. The disease is characterized by dysregulated immune activity resulting in malignant inflammation and multi-organ failure.

Feb 5, 2025 · Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of overwhelming inflammation (hyperinflammation) that causes multiorgan failure and death, making prompt and...

Hemophagocytic lymphohistiocytosis (HLH) covers a wide array of related life-threatening conditions featuring ineffective immunity characterized by an uncontrolled hyperinflammatory response. HLH is often triggered by infection.

Hemophagocytic lymphohistiocytosis (HLH) is a severe, systemic inflammatory syndrome that can be fatal. This syndrome can sometimes occur in people with medical problems that cause a strong activation of the immune system, such as an infection or cancer. HLH in these settings is called secondary HLH.