2024年2月28日 · In this study, we show that XBP1s, the major downstream effector of IRE1α, is required for HCC cell survival both in vitro and in vivo. Mechanistically, XBP1s transactivates …

2020年11月20日 · Genetic deletion of XBP1 has multiple consequences: some resulting from the loss of the transcription factor per se, and others related to compensatory activation of IRE1α. …

2018年4月15日 · 结果表明单宁酸能够联合顺铂增强肝癌 HepG2 细胞内质网应激 IRE1-XBP1 通路的激活水平，提示 IRE1-XBP1 通路可能是单宁酸和顺铂协同抗肝癌 HepG2 细胞的分子机制 …

XBP1 pathway activation increased in Huh7-Ntcp and HepG2 cells treated with bile acids, 6α-ethyl-chenodeoxycholic acid (6-ECDCA) or GW4064. This effect decreased with FXR …

In this study, we show that XBP1s, the major downstream effector of α IRE1 , is required for HCC cell survival both in vitro and in vivo. Mechanistically, XBP1s transactivates LEF1, a key co …

2017年4月1日 · HepG2 cells transfected with one of two different siRNAs directed to knock-down spliced XBP1 or with control siRNA were subsequently treated with IL6. We observed that …

Xbp1 mRNA splicing, JNK activation, and IRE1α-dependent RNA decay consistently correlate with increased activity of IRE1α in fructose-induced liver injury in hepatocyte-specific XBP1 …

2022年11月11日 · In vitro HepG2 cells or XBP1 knockout AML12 hepatocytes were stimulated with metformin, palmitic acid or small interfering RNA inducing XBP1 knockdown, or dominant …

In the present study the hepatitis B virus X antigen binding protein 1 (XBP1) was cloned by inducing its expression, and its subcellular localization and function were examined. Total RNA …

2007年3月1日 · In this study, the probable roles of HBx in GRP78 and XBP1 activation in transfected Hep3B and HepG2 cells were first examined by using a dual luciferase assay. The …