A key discovery in understanding fibrosis has been that the hepatic stellate cell (HSC) is the primary effector cell, orchestrating the deposition of ECM in normal and fibrotic liver. HSCs are resident perisinusoidal cells in the subendothelial space between hepatocytes and sinusoidal endothelial cells.

2021年2月8日 · In this study, we systematically analyzed proteomics of decellularized hepatic matrix and identified four unique clusters of ECM proteins at tissue damage/inflammation, transitional ECM...

The activated hepatic stellate cell (HSC) is primarily responsible for excess collagen deposition during liver fibrosis. Two important aspects are involved in mediating the fibrogenic response: first the HSC becomes directly fibrogenic by synthesizing ECM proteins; second, the activated HSC proliferates, effectively amplifying the fibrogenic ...

2021年7月23日 · In this review, we discuss the role of the ECM during liver fibrosis, including the main hepatic cell types and molecular pathways involved in this process, as well as the enzymes and ECM components that contribute and regulate …

Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound-healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture.

2020年8月15日 · Hepatic MFs contribute to fibrogenesis and CLD progression by well characterized pro-fibrogenic responses [6, 8, 10], including: i) increased synthesis of ECM components and altered remodeling of ECM, mainly in response to transforming growth factor β1 (TGFβ1), reactive oxygen species (ROS) and other oxidative stress-related mediators as well ...

Liver fibrosis is characterized by progressive accumulation of extracellular matrix (ECM), which destroys the physiological architecture of the liver . Pathogenetically, toxic, metabolic, or viral diseases lead to damaged hepatocytes and infiltration of immune cells that activate trans-differentiation of Hepatic stellate cells (HSCs) into ...

1 天前 · The hallmark of liver fibrosis is the excessive deposition of ECM, a process primarily mediated by HSCs. Under physiological conditions, HSCs remain in a quiescent state, residing in the space of Disse and contributing to hepatic homeostasis [3].However, upon liver injury, HSCs become activated by pro-fibrotic cytokines such as transforming growth factor-beta (TGF-β) and platelet-derived ...

2013年7月1日 · During resolution of liver fibrosis HSC can undergo programmed cell death (apoptosis) or reversion to a deactivated state with a reduction in ECM production. Using a CCl 4 -induced spontaneous resolution model, we have shown that whilst CD11b + macrophages are critical to fibrosis development, their deletion at the onset of spontaneous ...

The activated hepatic stellate cell (HSC) is primarily responsible for excess collagen deposition during liver fibrosis. Two important aspects are involved in mediating the fibrogenic response: first the HSC becomes directly fibrogenic by synthesizing ECM proteins; second, the activated HSC proliferates, effectively amplifying the fibrogenic ...