20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5 Z,8 Z,11 Z,14 Z -eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pat...

20-羟-二十烷四烯酸(20-hydroxyeicosatetraenoic acid,20-HETE)是花生四烯酸的细胞色素P-450代谢途径的一个重要代谢产物·近年来研究发现20-HETE对血管内皮细胞发挥重要的生理和病理生理作用·20-HETE可激活内皮细胞烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide phosphate,NADPH ...

5-Hydroxyeicosatetraenoic acid (5-HETE, 5 (S)-HETE, or 5S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid. It is produced by diverse cell types in humans and other animal species.

Lipoxygenases are a family of enzymes that are characterized as non-heme iron proteins or dioxygenases, which catalyse the abstraction of hydrogen atoms from bis -allylic positions (1 Z,4 Z -pentadiene groups) of polyunsaturated fatty acids followed by stereospecific addition of dioxygen to generate hydroperoxides.

20-HETE是治疗高血压的新靶点，参与血管生成，参与脑部认知障碍，在多个癌症靶点中有广泛的研究。 一方面，20-HETE是一种强效的血管收缩剂, 可以影响高血压的进展。在体外, 它可以通过血管紧张素II、血管内皮生长因子 (VEGF) 和血小板源性生长因子 (PDGF) 的诱导促进血管平滑肌细胞的迁移和增殖，通过收缩外周血管，并增强其血管活性物质的缩血管效应而起促高血压作用； 另一方面，20-HETE可以抑制肾脏近端小管和髓袢升支粗段对钠离子的重吸收，增加钠排泄并 …

2023年1月1日 · 20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid shown to be instrumental in the regulation of endothelial function, vascular tone, vascular remodeling and blood pressure; working alone and in concert with an array of mediators that influence vascular function.

20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid shown to be instrumental in the regulation of endothelial function, vascular tone, vascular remodeling and blood pressure; working alone and in concert with an array of …

12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z cis–trans configuration (Z=cis, E=trans) in its four double bonds.

12-脂氧合酶产物12s-hete由gpr31受体起作用，并促进肿瘤细胞增殖和转移，因此可能成为癌症治疗中有希望的靶标。 它也可能作为糖尿病的促炎介质。 相反，15

Arachidonic acid (AA) is metabolized by enzymes of the CYP4A and 4F families to 20-hydroxyeicosatetraeonic acid (20-HETE) which plays an important role in the regulation of renal function, vascular tone and the long term control of arterial ...