The dynamics of mitochondrial DNA heteroplasmy: implications
2015年8月18日 · At one extreme, very low-level mtDNA heteroplasmy seems to be an almost universal finding in healthy humans, and the transmission of such heteroplasmic variants down …
Heteroplasmy - Wikipedia
Heteroplasmy is the presence of more than one type of organellar genome (mitochondrial DNA or plastid DNA) within a cell or individual. It is an important factor in considering the severity of …
Heteroplasmy - an overview | ScienceDirect Topics
Heteroplasmy is a condition where two or more different variants of mtDNA coexist within a cell. This can refer either to the presence of two normal variants, i.e. different healthy mtDNA …
Mitochondrial DNA Genetics and the Heteroplasmy Conundrum …
The heteroplasmy variance of offspring or derived cells is a function of the heteroplasmy level of the mothers for offspring or of the parental cells for derived cells, the parental heteroplasmy …
Heteroplasmy - an overview | ScienceDirect Topics
Heteroplasmy describes the situation in which two or more mtDNA variants exist within the same cell. Heteroplasmies are often caused by de novo mutations occurring either in the germline or …
Mitochondrial DNA heteroplasmy in disease and targeted …
Patients with high heteroplasmy for deleterious mtDNA species will likely suffer from bona‐fide mitochondrial diseases, which currently have no cure. Shifting mtDNA heteroplasmy toward …
Heteroplasmy and Individual Mitogene Pools: Characteristics and ...
Technically, heteroplasmy refers to the presence of more than one type of mitochondrial DNA (mtDNA) in an individual . Heteroplasmy is a copy-level mitogenome variation, and each cell, …
Heteroplasmy - an overview | ScienceDirect Topics
In contrast, when there is a variation of the mtDNA sequence between different mtDNA molecules within an individual cell (i.e., there are two populations of mtDNA), this is known as …
Heteroplasmy and Individual Mitogene Pools: Characteristics and …
2023年11月20日 · A mitochondrion, cell, tissue, organ, or an individual body may hold multiple variants, both inherited and developed over a lifetime, which make up individual mitogene …
Nuclear genetic control of mtDNA copy number and heteroplasmy …
2023年8月16日 · Heteroplasmy refers to the presence of a mixture of mtDNA alleles in an individual and has been associated with disease and ageing.