A hexokinase is an enzyme that irreversibly phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product.

Hexokinase is a type of sugar kinase that plays a key role in the phosphorylation of glucose, which is the initial step in glucose metabolism. It binds to mitochondria, regulates ATP production, and is crucial for cell survival.

2024年2月27日 · The hexokinase method is a diagnostic test that accurately measures glucose concentration in biological fluids. This method is commonly used to estimate plasma glucose levels and is highly accurate and robust.

Hexokinase II phosphorylates glucose to regulate glucose metabolism but also functions as a protective signaling molecule. Hexokinase II is the predominant isoform in insulin-sensitive tissues and upregulated in tumors. Hexokinase II expression is regulated by the Akt/mTOR pathway.

3D structures of hexokinase. Hexokinase. Additional Resources. For additional information, see: Carbohydrate Metabolism. References. ↑ Pollard-Knight D, Cornish-Bowden A. Mechanism of liver glucokinase. Mol Cell Biochem. 1982 Apr 30;44(2):71-80. PMID:7048063; ↑ Koshland D. Induced Fit and Hexokinase.Fig.7 Active Site of Glucokinase ...

Hexokinase expression is regulated in cancer cells at the transcriptional, mRNA, and protein levels. Under hypoxic conditions, HKs, including HK3, is transcriptionally upregulated in a hypoxia-induced-factor (HIF)-1-dependent manner (Nakajima et …

Hexokinase (HK) is an enzyme that catalyzes the phosphorylation of glucose during glycolysis and has five isoenzymes in mammalian tissues (HK1, HK2, HK3, glucokinase, and HKDC1). HK1 and HK2 are known to bind to VDAC, inhibit its activity, and attenuate cell apoptosis ( 57 , 70 ).

Hexokinase is an enzyme that catalyzes the phosphorylation of glucose to form glucose-6-phosphate, a critical first step in the glycolysis pathway. This reaction is essential for cellular energy production as it traps glucose within the cell and prepares it for further breakdown during glycolysis, linking metabolism to energy utilization in cells.

2024年7月25日 · Here, we discovered that hexokinase 1 (HK1), a key glycolytic enzyme, forms rings around mitochondria during energy stress. These HK1-rings constrict mitochondria at contact sites with the endoplasmic reticulum (ER) and mitochondrial dynamics protein (MiD51).

Hexokinase I, also known as hexokinase A and HK1, is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways.