Hexafluoroisopropanol, commonly abbreviated HFIP, is the organic compound with the formula (CF 3) 2 CHOH. This fluoroalcohol finds use as solvent in organic chemistry. [1] Hexafluoro-2-propanol is transparent to UV light with high density, low viscosity and low refractive index. It is a colorless, volatile liquid with a pungent odor.

1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. [1] . This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. [2] .

Aug 14, 2023 · Hexafluoro-2-propanol (erroneously called “hexafluoroisopropanol”, abbreviated HFIP) is a low-boiling solvent used in a variety of chemical applications.

Oct 14, 2021 · 1,1,1,3,3,3-hexafluoro-2-propanol HFIP | C6H4F12O2 | CID 87445672 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Mar 4, 2024 · In the past 5 years, hexafluoroisopropanol (HFIP) has been used as a unique solvent or additive to enable challenging transformations through substrate activation and stabilization of reactive intermediates. In this Review, we aim at describing difunctionalization processes which were unlocked when HFIP was involved.

Nov 8, 2017 · 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) has recently become a very popular solvent or additive with applications across the spectrum of chemistry. Analysis shows that it possesses...

Jul 17, 2022 · 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic species, transfer protons, and engage in a range of other intermolecular interactions.

Jan 27, 2025 · 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic. Uses. Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry. Uses

Hexafluoroisopropanol (HFP) is generally used to denature the native state of proteins, and it also stabilizes the a-helical conformation in unfolded peptides and proteins like ß-lactoglobulin and melittin. [1] Suitable for the derivatization of glutamic acid, homovanillic, iso-homovanillic and dihydroxyphenyl acetic acids and Υ-aminobutyric acid.

IUPAC Standard InChIKey: BYEAHWXPCBROCE-UHFFFAOYSA-N Copy CAS Registry Number: 920-66-1 Chemical structure: This structure is also available as a 2d Mol file or as a ...