2022年4月1日 · Hypofractionated radiotherapy (HFRT) is currently recommended by several international guidelines for early breast cancer without nodal involvement and after breast conservative surgery. However, due to limited available data on HFRT, in cases of regional nodal irradiation, the optimal schedule in locally advanced breast cancer in such cases ...

摘要： 目的 探讨不同放疗分割模式即大分割放疗（hypofractionated radiotherapy, HFRT)和常规分割放疗（conventional fractionation radiotherapy, CFRT)对乳腺癌患者外周血淋巴细胞的影响。 方法 回顾性分析2019年11月至2021年8月在徐州市中心医院接受保乳术后放射治疗的40例早期乳腺癌患者。 随机分为观察组（HFRT， n = 20）与对照组（CFRT， n = 20），比较2组患者放疗前及放疗中的外周血淋巴细胞计数 (peripheral lymphocyte count，PLC)变化。

Hypofractionated RT (HFRT) regimens, in which radiation is administered using larger doses per fraction over a shorter period of time, are becoming increasingly common.

Application of hypofractionated radiotherapy (HFRT) is growing in patients with breast cancer (BC). This study aimed to explore a real-world practice of HFRT in early and locally advanced BC. Patients with invasive BC between 2015 and 2019 were ...

Compared with survival data for standard treatment, HFRT seemed to improve overall survival and progression-free survival, while high BED schedules may future increase benefit on PFS. Meanwhile, the toxicity of HFRT was tolerable. Further randomised controlled clinical studies are needed to confirm …

2024年10月1日 · Hypofractionated RT (HFRT) is the delivery of larger radiation doses (> 2.2Gy) per fraction over a shorter treatment duration. While HFRT improves patient compliance, data on its safety and efficacy in the treatment of cervical cancer are scarce.

Moderately hypofractionated RT (HFRT) regimens for prostate cancer with a fraction size of 2.4–4 Gy over 4–6 weeks have shown non-inferior efficacy and similar toxicities in clinical trials [8 - 11]. Hypofractionation offers advantages, such as shorter overall treatment time, reduced cost, and improved patient compliance.

sbrt或hfrt具有治疗时间短、急性毒性小、顺应性好等优点，但也有可能对器官造成永久性损伤。一些研究报道了sbrt和hfrt对老年头颈癌患者的疗效和毒性(表4)。 表4。报告老年患者hfrt结果的研究。 1. sbrt

2024年5月27日 · The effectiveness and safety of moderately hypofractionated radiotherapy (HFRT) in patients undergoing breast-conserving surgery (BCS) has been demonstrated in several pivotal randomized trials. However, the feasibility of applying simultaneous integrated boost (SIB) to the tumor bed and regional node irradiation (RNI) using modern radiotherapy ...

为进一步评估三联治疗方案的临床疗效，卢铀教授团队还回顾性分析了9例接受 LDRT+HFRT+免疫治疗的晚期非小细胞肺癌患者（多为2线或以上治疗失败的患者）。 结果显示 3例患者最佳疗效达到PR，2例患者为SD；中位PFS达到3.7个月，中位OS尚未达到。 值得一提的是，9例患者接受LDRT的病灶靶体积均较大（175.7 ± 42.3 cm3），平均放疗剂量仅为4.9Gy（2-8Gy），治疗后6例患者观察到LDRT病灶体积缩小，其平均缩小体积为28%。 回顾性数据中未观察到3级及以上 …