2022年10月10日 · Live-imaging of Madin-Darby canine kidney (MDCK) cells and mouse epidermis through the use of Förster resonance energy transfer (FRET)-based biosensors showed that leader cells exhibit sustained ERK activation in a hepatocyte growth factor (HGF)-dependent manner.

2001年11月2日 · In this study, we showed that HGF induced ERK activity in MKN74 cells, the proliferation of which is stimulated by HGF. In addition, we found that a MEK inhibitor blocked the proliferation stimulation, suggesting that the ERK pathway plays a crucial role in the HGF-induced proliferation stimulation of the human gastric carcinoma cell line.

2022年10月10日 · Lamellipodial extension at the free edge increases the cellular sensitivity to HGF. The HGF-dependent ERK activation, in turn, promotes lamellipodial extension, thereby forming a positive feedback loop between cell extension and ERK activation and specifying the cells at the free edge as the leader cells.

2019年8月16日 · Hepatocyte growth factor (HGF) signaling through its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and progression. Met interaction with integrins is shown to...

Here, we show that lamellipodial extension after the release from mechanical confinement causes sustained extracellular signal-regulated ki-nase (ERK) activation and underlies the leader cell specification.

2001年8月1日 · Consistent with this data, we now show that inhibition of ERK activation prevents the HGF-mediated decrease in Gab1 gel mobility, arguing that ERK may directly phosphorylate Gab1 following HGF stimulation.

2017年8月25日 · It has been shown that the HGF/c-Met axis plays crucial roles in adult liver regeneration, embryonic organ development and wound healing 6 through phosphoinositide 3-kinase (PI3K)/Akt and Ras/Raf...

2002年4月16日 · These data indicate that HGF/SF induces a RAS-RAF-MEK-ERK pathway, which leads to the phosphorylation and activation of ETS1, RAS-dependent transcriptional responses and cell scattering and ...

2001年11月2日 · We have investigated the intracellular signaling pathway involved in the antiproliferative effect of HGF on the human hepatocellular carcinoma cell line HepG2. HGF induced strong activation of ERK in HepG2 cells.

其中,细胞外信号调节激酶/丝裂原活化蛋白激酶(erk/mapk)信号通路和神经营养因子(cntf)信号通路的信号传导活动与对照差异极显著(p≤0.01),肝细胞生长因子(hgf)信号通路和胚胎肝细胞多能性(esm)信号通路的信号传导活动与对照差异显著(p≤0.05),说明上述4条信号通路 ...