Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

Hepatocyte growth factor (HGF) is a mesenchyme-derived mitogen that also stimulates cell migration, and branching and/or tubular morphogenesis of epithelial and endothelial cells. In the present study, we tested the hypothesis that simultaneous administration of HGF and VEGF would synergistically promote new blood vessel formation.

Recombinant, human hepatocyte growth factor expressed in S. frugiperda insect cells. Pleiotropic growth factor that has also been called scatter factor, hepatopoietin A, and mammary growth factor. Through binding to its high affinity met receptor, HGF has marked and varied effects on hepatocytes and other epithelial and endothelial cell types.

肝细胞生长因子（HGF），是一类由间充质细胞分泌的糖基化异源二聚体，由二硫键连接的α链（约57 kDa）和β链（约26 kDa）组成 [1]，常以非活性形式存在于多种细胞外基质中 [2]。 作为c-MET的单独配体，HGF作用于各种上皮细胞，以旁分泌方式结合并激活下游 Ras-MAPK 、 PI3K-AKT 、 STAT 、 β-链整联蛋白 和 GAB 1 等信号分子介导的各种信号传导通路，从而调节细胞生长、增殖、迁移、存活、运动和形态变化、分化等各种过程 [1]。 图1.HGF/c-MET信号通路. 成 …

肝细胞生长因子 (hgf)，也是分散因子 (sf)，是一种旁分泌细胞生长、运动和形态形成因子。 它由间充质细胞和靶细胞分泌，主要作用于上皮细胞和内皮细胞，但也作用于造血祖细胞和 T 细胞。

HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates

Jun 2, 2019 · Background: HGF/MET pathway may have a role in pulmonary hypertension (PH). However, the link between the pathway and development of target organ damage in PH remains elusive. We aimed to demonstrate the relation between plasma HGF and HGF/MET tissue expressions in affected organs during PH progression.

肝细胞生长因子（hgf）是作为一种能刺激肝细胞增殖的物质而发现的，后来发现hgf还能作用于上皮细胞、造血细胞、血管内皮细胞等多种细胞，是一种可调节多种细胞生长、运动和形态发生的多功能因子。

Hepatocyte growth factor (HGF), a potent mitogen for mature hepatocytes in primary culture, was first found in sera of partial hepatectomized rats and seems to be a hepatotrophic factor for liver regeneration which has not been purified over the past 30 years.

Liver sinusoidal endothelial cells (LSECs) control organ functions, metabolism, and development through the secretion of angiokines. LSECs express hepatocyte growth factor (Hgf), which is involved in prenatal development, metabolic homeostasis, and liver regeneration. This study aimed to elucidate t …