肝细胞生长因子 (hgf)，也是分散因子 (sf)，是一种旁分泌细胞生长、运动和形态形成因子。 它由间充质细胞和靶细胞分泌，主要作用于上皮细胞和内皮细胞，但也作用于造血祖细胞和 T 细胞。

hgf具体的生物学功能包括以下三个方面： 1、具有促进血管内皮细胞增生和新生血管形成的作用，一般认为在血管生成过程中，内皮细胞需要表现出一系列特殊、复杂的行为，包括增殖、迁移、细胞间互相黏着、排成直线以及形成开放的腔样结构，HGF刺激新生 ...

肝细胞生长因子 (HGF，又称 Scatter Factor) 是一类具有血管生成能力的因子。HGF最初被发现为上皮细胞的成纤维细胞源性细胞动力因子。它由间充质细胞、成纤维细胞和平滑肌细胞合成。

Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

研究团队将从手术获得的肝祖细胞进行体外培养，通过添加重组人肝细胞生长因子（HGF）等细胞因子，成功衍生出肝脏类器官（HLOs），这一模型为探究NAFLD的发病机制提供了有力的工具。 研究发现，雌激素驱动的ER-α与下游配体的结合可促进高遗传风险变体PNPLA 3 p.I148M在肝细胞内脂滴中的合成和蓄积，这一发现揭示了雌激素在NAFLD发病机制中的重要作用。 代谢功能障碍相关脂肪肝病（MASLD）是一类进行性疾病，其肝再生机制已在动物模型内得到了研究，不 …

肝细胞生长因子（HGF）是作为一种能刺激肝细胞增殖的物质而发现的，后来发现HGF还能作用于上皮细胞、造血细胞、血管内皮细胞等多种细胞，是一种可调节多种细胞生长、运动和形态发生的多功能因子。 通过旁分泌或自分泌机制，借助上皮间质的相互作用，在胚胎发生、创伤愈合、血管发生、组织器官再生、形态发生和致癌作用等方面发挥重要作用。 HGF存在于动物和人体内多种组织和细胞中，主要来源于肝脏Kupffer细胞、内皮细胞、成纤维细胞、贮脂细胞、肺脏内皮细 …

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine ...

2021年12月14日 · CM1021 is a fusion protein containing the K1 loop of HGF and the human IgG1 Fc region. The experiments described here demonstrate that CM1021 has the biological properties of HGF and the pharmacological properties of a monoclonal antibody. CM1021 stimulates scattering and branching morphogenesis in MDCK cells and stimulates liver growth in …

2017年4月17日 · 成纤维细胞是肿瘤基质的主要成分，肝细胞生长因子 (HGF) 是酪氨酸激酶受体 c-MET 的特异性配体，是其分泌组的主要成分。 事实上，癌症相关成纤维细胞已被证明以 HGF 依赖性方式促进癌细胞的生长、存活和迁移。 成纤维细胞还通过 HGF 诱导的上皮间充质转化 (EMT) 和激活肿瘤细胞中促存活信号通路如 ERK 和 AKT 来赋予抗癌治疗抗性。 癌细胞中的组成型 HGF/MET 信号传导与肿瘤侵袭性增加有关，并预测癌症患者的不良预后。 由于其在肿瘤进展 …

Hepatocyte growth factor (HGF) and its high-affinity receptor, mesenchymal epithelial transition factor (c-Met), are closely related to the onset, progression and metastasis of multiple tumors. The HGF/c-Met axis has a pivotal role in normal liver growth, regeneration, and protection (Giordano and Columbano, 2014).

Hepatocyte growth factor (HGF), a pleiotropic cytokine of mesenchymal origin promoting migration, proliferation, and survival in a wide spectrum of cells, can also modulate different biological responses in stem cells, but the mechanisms involved are not completely understood so far. In this context …

Hepatocyte growth factor/scatter factor (HGF/SF) is an important humoral mediator of liver regeneration and related to molecular mechanisms of hepatocarcinogenesis via paracrine system involving its cellular receptor, c-met.

Hepatocyte growth factor (HGF; scatter factor) is a multipotent protein with mitogenic, motogenic, and developmental functions. Upon activation, the HGF-receptor c-Met binds and phosphorylates the multisite docking protein Gab1.

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a pleotropic factor required for normal organ development during embryogenesis. In the adult, basal expression of HGF maintains tissue homeostasis and is up-regulated in response to tissue injury.

2001年1月15日 · We now report that HGF induces directional migration and cytokine secretion in human monocytes. Monocyte activation by endotoxin and IL-1β results in the up-regulation of the HGF receptor expression and in the induction of cell-associated pro-HGF convertase activity, thus enhancing cell responsiveness to the factor.

Hepatocyte growth factor/scatter factor (HGF/SF) plays critical roles in cancer progression through its specific receptor, MET. HGF/SF is usually synthesized and secreted as an inactive proform (pro-HGF/SF) by stromal cells, such as fibroblasts.

2024年12月18日 · 研究团队将从手术获得的肝祖细胞进行体外培养，通过添加重组人肝细胞生长因子（HGF）等细胞因子，成功衍生出肝脏类器官（HLOs），这一模型为探究NAFLD的发病机制提供了有力的工具。 研究发现，雌激素驱动的ER-α与下游配体的结合可促进高遗传风险变体PNPLA 3 p.I148M在肝细胞内脂滴中的合成和蓄积，这一发现揭示了雌激素在NAFLD发病机制中的重要作用。 代谢功能障碍相关脂肪肝病（MASLD）是一类进行性疾病，其肝再生机制已在动物模型 …

2022年8月3日 · The prominent therapeutic effect of HGF/MSCs comes from both HGF and MSC. HGF has angiogenesis, anti-fibrosis and anti-inflammation properties; the overexpression of HGF in vivo is beneficial to many conditions. HGF gene modification promotes the in vivo survival rate of MSC, hence improving the MSCs' therapeutic effect.

2002年7月31日 · In this study, we measured serum HGF concentrations of blood samples and conducted prospective studies to examine the long-term outcome of C-viral chronic hepatitis (CH) and cirrhosis in patients. The subjects examined in this study include 99 patients with C-viral CH, cirrhosis, and HCC.

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