Feb 8, 2025 · Hepatocyte growth factor regulates the development of highly pure cultured chief cells from rat stomach by stimulating chief cell proliferation in vitro. Tashima K, et al. Am J Physiol Gastrointest Liver Physiol, 2009 Feb. PMID 19023030, Free PMC Article.

Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

肝细胞生长因子 (HGF，又称 Scatter Factor) 是一类具有血管生成能力的因子。 HGF最初被发现为上皮细胞的成纤维细胞源性细胞动力因子。 它由间充质细胞、成纤维细胞和平滑肌细胞合成。 活性 HGF 是一种由重链 (α链，62 kDa) 和轻链 (β链，32-36 kDa) 组成的异质二聚体，它们通过二硫键连接在一起。 HGF 通过与 c-Met 受体结合来发挥其生物学功能 (例如增殖/分化/存活/运动发生)。 HGF/c-Met 信号轴以旁分泌的方式参与上皮器官的发育，发挥上皮的再生作用，并促进许 …

Dec 25, 2024 · HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

Apr 1, 2015 · Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

HGF，即肝细胞生长因子，别名DFNB39、FTCF、Hepatopoietin-A、HGFB、HPTA。 它是一种由肝脏、内皮细胞、成纤维细胞等多种细胞产生的多效性细胞因子。 HGF的作用机制主要是通过与其受体c-Met结合，激活下游的多种信号通路，如PI3K/AKT、RAS/RAF/MEK/ERK等，促进细胞的增 …

肝细胞生长因子（HGF）是作为一种能刺激肝细胞增殖的物质而发现的，后来发现HGF还能作用于上皮细胞、造血细胞、血管内皮细胞等多种细胞，是一种可调节多种细胞生长、运动和形态发生的多功能因子。 通过旁分泌或自分泌机制，借助上皮间质的相互作用，在胚胎发生、创伤愈合、血管发生、组织器官再生、形态发生和致癌作用等方面发挥重要作用。 HGF存在于动物和人体内多种组织和细胞中，主要来源于肝脏Kupffer细胞、内皮细胞、成纤维细胞、贮脂细胞、肺脏内皮细 …

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.

Hepatocyte growth factor (HGF) is a most potent factor for mature parenchymal hepatocytes in primary culture and may act as a trigger for liver regeneration. We purified HGF from rat platelets to homogeneity and cloned both human and rat HGF cDNA. HGF is a heterodimer molecule composed of the 69 kDa alpha-subunit and the 34 kDa beta-subunit.

Transforming growth factor-beta (TGF- β) and hepatocyte growth factor (HGF) are inflammatory cytokines which function as key regulators of immunological homeostasis and inflammatory responses. They have been linked to inflammatory bowel diseases (IBD).