HGF receptor is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the HGF receptor.

Under normal conditions, hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand delivery, ligand activation at the target cell surface, and ligand activated receptor internalization and degradation.

Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

The hepatocyte growth factor receptor, MET, is a proto-oncogene and a prototypical transmembrane tyrosine kinase receptor. Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis.

HGFR. Hepatocyte growth factor receptor (HGFR), also known as Met, is an RTK that likely has protective effects against post-MI cardiomyocyte apoptosis. HGF binds its HGFR/Met receptor with high affinity. Oxidative stress generates proteins that activate the apoptotic pathway in cardiomyocytes.

One promising target is the signaling pathway of hepatocyte growth factor (HGF, also known as scatter factor, SF) along with its receptor (HGFR, also known as c-Met). HGF, a potent mitogenic, motogenic and morphogenic factor that also plays an important role in angiogenesis and tumor growth (14 – 16).

Our data indicate that the Met/HGFR gene is deregulated in a few cases of human leukemia, Burkitt's lymphoma and Hodgkin's disease possibly by chromosomal rearrangements resulting in an overexpression of the normal Met/HGF receptor mRNA …

Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine kinase.

The HGF receptor (HGFr) is the product of the c-met proto-oncogene, a membrane-spanning tyrosine kinase receptor. The 190-kDa precursor is proteolytically processed within the extra-cellular domain (ECD) to a heterodimer consisting of a …

2016年6月1日 · Hepatocyte growth factor (HGF) signaling via the MET receptor is essential for embryonic development and tissue repair. On the other hand, deregulated MET signaling promotes tumor progression in diverse types of cancers.