HGF receptor is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the HGF receptor.

We review here Met structure and function, the basic properties of HGF/Met pathway antagonists now in preclinical and clinical development, as well as the latest clinical trial results.

2024年12月25日 · Mesenchymal Epithelial Transition MET is a prototypical receptor tyrosine kinase. Its ligand is Hepatocyte Growth Factor (HGF). MET alterations are drivers of human cancer. Amplification and resulting overexpression has been reported in several cancers, and make the receptor's activity independent of HGF.

Hepatocyte growth factor (HGF) was originally reported in 1984 to be a mitogenic protein for mature hepatocytes in primary culture. The primary structure of HGF became evident with cDNA cloning in 1989. HGF was then found to be a novel growth factor structurally distinct from other known growth factors.

The HGF receptor (MET) is a prototypal tyrosine kinase receptor which plays a key role in the interaction between mesenchyme and epithelia during embryogenesis and tissue homeostasis [4].

c-Met，也称为酪氨酸蛋白激酶Met或肝细胞生长因子受体（HGFR），是人类中由MET基因编码的蛋白，具有酪氨酸激酶活性。 初级单链前体蛋白在翻译后被切割以产生α和β亚基，其被二硫键连接以形成成熟受体。 癌症中的异常MET活化与预后差相关，其中异常活跃的MET 引发肿瘤生长，形成新的血管为肿瘤提供营养物并有助于癌症转移。 MET在许多恶性肿瘤中失调，包括肾癌、肝癌、胃癌、乳腺癌和脑癌。 通常情况下，仅干细胞和祖细胞中表达MET，允许这些细胞生长，在 …

Our results indicate that HGF and HGFR gene expression is inducible and their expression is orchestrated in stromal and epithelial cells, respectively, by extracellular signals derived from steroid hormones as well as cytokines such as IL-1, IL-6, and TNFα. These keywords were added by machine and not by the authors.

Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding. The receptor for hepatocyte growth factor (HGF) is the product of the c-met proto-oncogene, a membrane- spanning tyrosine kinase receptor.

肝细胞生长因子（HGF）是作为一种能刺激肝细胞增殖的物质而发现的，后来发现HGF还能作用于上皮细胞、造血细胞、血管内皮细胞等多种细胞，是一种可调节多种细胞生长、运动和形态发生的多功能因子。 通过旁分泌或自分泌机制，借助上皮间质的相互作用，在胚胎发生、创伤愈合、血管发生、组织器官再生、形态发生和致癌作用等方面发挥重要作用。 HGF存在于动物和人体内多种组织和细胞中，主要来源于肝脏Kupffer细胞、内皮细胞、成纤维细胞、贮脂细胞、肺脏内皮细 …

Hepatocyte growth factor (HGF) exhibits mitogenic and/or motogenic activities for a variety of cells (see for review Matsumoto and Nakamura, 1992). Structurally, it has similarities to kringle-containing serine-proteases, although it does not possess proteolytic activity.