BiGG Reaction: HHDDH
Latest BiGG Models publication: King ZA, Lu JS, Dräger A, Miller PC, Federowicz S, Lerman JA, Ebrahim A, Palsson BO, and Lewis NE. BiGG Models: A platform for ...
Stereoselective Synthesis of Oxetanes Catalyzed by an Engineered ...
2024年12月9日 · Halohydrin dehalogenases (HHDHs) are industrially relevant enzymes that have been engineered to accomplish the reversible transformation of epoxides. In this study, a …
Enhancing the biocatalytic manufacture of the key intermediate of ...
2017年2月6日 · Halohydrin dehalogenases (HHDHs, EC 4.5.1.X), also known as halohydrin epoxidases or halohydrin hydrogen-halide-lyases, are microbial enzymes that catalyze the …
Rational design of halohydrin dehalogenase for efficient chiral ...
2020年9月15日 · Halohydrin dehalogenase (EC4.5.1.X, HHDH) is one of the key enzymes catalyzing the reversible dehalogenation of β-haloalcohols with the formation of epoxide. It is …
Recent advances on halohydrin dehalogenases—from enzyme
2016年8月8日 · These enzymes, also called halohydrin dehalogenases (HHDHs), haloalcohol dehalogenases, or halohydrin hydrogen-halide-lyases, belong to the enzyme class of lyases …
Intact-cell detection of halohydrin dehalogenase activity and ...
2024年11月1日 · Halohydrin dehalogenase (HHDH) can degrade 1,2,3-trichloropropanol and other halogenated alcohols. These enzymes exhibit stereoselectivity and can be used to …
HheG, a Halohydrin Dehalogenase with Activity on Cyclic Epoxides
2017年9月13日 · Halohydrin dehalogenases (HHDHs) are of biotechnological interest due to their promiscuous epoxide ring-opening activity with a set of negatively charged nucleophiles, …
Properties and biotechnological applications of halohydrin ...
2012年11月1日 · Halohydrin dehalogenases (HHDHs) are lyases that catalyze the cleavage of carbon–halogen bond of halohydrins. They also can catalyze the reverse reaction in the …
Insights into the molecular determinants of thermal stability in ...
Halohydrin dehalogenases (HHDHs) are promising enzymes for application in biocatalysis due to their promiscuous epoxide ring-opening activity with various anionic nucleophiles. So far, …
Conformational Landscapes of Halohydrin Dehalogenases and …
2020年12月1日 · Halohydrin dehalogenases (HHDH) are industrially relevant biocatalysts exhibiting a promiscuous epoxide-ring opening reactivity in the presence of small nucleophiles, …