2024年12月25日 · HIF3A (Hypoxia Inducible Factor 3 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF3A include Subglottis Benign Neoplasm and Renal Cell …

HIF1α and HIF2α are the best characterized and structurally similar isoforms, while HIF3α is the most distantly related and is less studied. The HIF3α gene undergoes complex regulation and …

Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene. [5][6][7] The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta …

且与前2种不同的是HIF-3α有多种剪切体，如：老鼠中包括全长的鼠HIF-3α (mHIF-3α)，抑制性PAS结构域蛋白 (inhibitory PAS domain protein, IPAS)，新生儿和胚胎PAS蛋白 (neonatal …

HIF-3α在蛋白质结构和基因表达调控方面不同于HIF-1α和HIF-2α。 长期以来，HIF-3α被认为是HIF调控基因的负介体。 HIF-3具有转录调节功能，在缺氧期间通过与HIF-1α和HIF-2α竞争结 …

2025年2月8日 · HIF3A is regulated by hypoxia in the developing human lung. Hypoxia upregulated transcription from all three alternative HIF-3alpha promoters. siRNA experiments …

由该基因编码的蛋白质是几种 alpha/beta 亚基异二聚体转录因子之一的 alpha-3 亚基，这些转录因子调节许多对低氧张力 (缺氧) 的适应性反应。 alpha-3 亚基缺少在包含 alpha-1 或 alpha-2 亚 …

2015年10月28日 · HIF1α and HIF2α are the best characterized and structurally similar isoforms, while HIF3α is the most distantly related and is less studied. The HIF3α gene undergoes …

2025年2月8日 · HIF-3α Promotes Metastatic Phenotypes in Pancreatic Cancer by Transcriptional Regulation of the RhoC-ROCK1 Signaling Pathway. DNA Methylation and BMI: Investigating …

2006年6月15日 · HIF-3α was strongly induced by hypoxia (1% O 2) both at the level of protein and mRNA due to an increase in protein stability and transcriptional activation, whereas HIF …