PDAC is characterized histologically by extensive desmoplastic stroma, a hypoxic and immunosuppressive tumor microenvironment (TME) consisting of cancer-associated fibroblasts (CAFs), stellate cells (SC), an extracellular matrix, endothelial cells, myeloid-derived suppressor cells, and low number of tumor-infiltrating lymphocytes (TILs).

2021年6月15日 · Pancreatic ductal adenocarcinoma (PDAC) is an invasive pancreatic epithelial neoplasm with glandular (ductal) differentiation, usually demonstrating luminal or intracellular mucin and without a substantial component of any other histological type

2019年6月2日 · Neoplasms of the pancreas comprise a broad spectrum and are generally classified according to their histological differentiation as epithelial or non-epithelial and according to their biological behaviour in benign, pre-malignant or malignant neoplasms.

2021年11月14日 · Accurate macroscopic and microscopic examination plays a crucial role in the management of pancreatic adenocarcinoma, including grossing, histopathological tumor grading, resection margin evaluation, lymph node status, tumor regression grading, and …

2019年6月2日 · Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and estimated to become the second leading cause of cancer-related deaths by 2030. Although overall 5-year survival rates have constantly remained below 10% for the last decades, several key points important for accurate patie …

Three distinct molecular PDAC subtypes [“classical”, “quasi-mesenchymal” (QM) and “exocrine-like”] with prognostic relevance and distinct drug response were defined based on combined analysis of transcriptional profiles of primary tumor samples and …

Histological and molecular data of MSI/dMMR PDAC were compared with non-MSI/dMMR PDAC and with PDAC reference cohorts (including SEER database and The Cancer Genome Atlas Research Network - TCGA project). Results: Overall, 34 studies with 8323 patients with PDAC were included in the systematic review. MSI/dMMR demonstrated a very low prevalence ...

2006年5月15日 · The well-defined serial histopathologic picture and accompanying molecular profiles of PDAC and its precursor lesions have provided the framework for emerging basic and translational research.

Histopathological diagnosis of pancreatic ductal adenocarcinoma (PDAC) on endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) specimens has become the mainstay of...

2020年4月29日 · Histological and molecular data of MSI/dMMR PDAC were compared with non-MSI/dMMR PDAC and with PDAC reference cohorts (including SEER database and The Cancer Genome Atlas Research Network - TCGA project). Overall, 34 studies with 8323 patients with PDAC were included in the systematic review.