2020年12月11日 · Our study shows that histone acylation acts as an immediate and reversible metabolic sensor enabling cellular adaptation to metabolic stress by reprogramming gene expression.

Many types of histone lysine acylations are known today. This review discusses how histone acylations impact chromatin dynamics, their biological relevance, and how local CoA availability might couple cellular metabolisms with the epigenome.

2024年6月6日 · In this Cell Science at a Glance article and the accompanying poster, we focus on these histone acylation modifications and provide an overview of the players that govern these acylations and their connections with metabolism.

2024年6月1日 · In this Cell Science at a Glance article and the accompanying poster, we focus on these histone acylation modifications and provide an overview of the players that govern these acylations and their connections with metabolism.

By analyzing the specific and dynamic acylation levels of H3K23 as an epigenetic marker, we found that the epigenome actively responds to metabolic changes to alleviate metabolic stress by genome-wide remodeling of histone acylation.

2016年12月7日 · Histone Lys acylations are modulated by the cellular metabolism of cognate short-chain acyl-CoA species. The novel histone Lys acylations are recognized by specific protein domains and can be...

Our study shows that histone acylation acts as an immediate and reversible metabolic sensor enabling cellular adaptation to metabolic stress by reprogramming gene expression.

2023年6月24日 · Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. Abnormal acylation is strongly associated with various diseases, such as cancer.

We propose a model to explain our present understanding of how differential histone acylation is regulated by the metabolism of the different acyl-CoA forms, which in turn modulates the regulation of gene expression.

a Modulating enzyme activity using small molecule mediators of enzymes.b Promoting epigenetic histone lysine acetylation using a chemical catalyst and an exogenous chemical reagent in live cells 15. c A chemical surrogate for a HAT enzyme utilizing only cellular metabolites to promote histone lysine acylation in live cells, reported in this work.. We previously developed the …