This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.

2024年12月25日 · HLA-DMA (Major Histocompatibility Complex, Class II, DM Alpha) is a Protein Coding gene. Diseases associated with HLA-DMA include Chediak-Higashi Syndrome and Autoimmune Disease. Among its related pathways are TCR Signaling (Qiagen) and Immune response NFAT in immune response.

HLA-DMA 属于 HLA II 类α链旁系同源物。这种 II 类分子是一种异二聚体，由一条 alpha (DMA) 和一条 beta 链 (DMB) 组成，两者都锚定在膜中。它位于细胞内囊泡中。 DM 通过帮助从肽结合位点释放 CLIP 分子，在 MHC II 类分子的肽加载中起着核心作用。

HLA-DMA may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism. The results suggest that HLA-DMA*0104 may represent a novel allele of susceptibility to systemic lupus erythematosus. HLA-DMA belongs to the HLA class II alpha chain paralogues.

HLA-DMA属于HLA II类α链平行系。 这个II类分子是一个由α (DMA)和β链 (DMB)组成的核心异二聚体，两者都固定在膜上。 它位于细胞内囊泡中。 DM在MHC II类分子的肽加载中扮演着关键角色，帮助从肽结合位点释放CLIP分子。 II类分子在抗原呈递细胞（APC：B淋巴细胞，树突状细胞，巨噬细胞）中表达。 α链约为33-35 kDa，其基因包含5个外显子。 外显子1编码前导肽，外显子2和3编码两个细胞外结构域，外显子4编码跨膜结构和细胞质尾。 [由RefSeq，2008年7月提 …

2023年11月6日 · HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles.

2024年6月17日 · HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles.

HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles.

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles.

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alp ha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles.