2018年9月3日 · We compared the overall gene expression profile of poorly-differentiated (HLE, HLF, SNU-449) to well-differentiated (HUH7, HEPG2, HEP3B) HCC cell lines in three publicly …

肝细胞癌（hepatocellularcarcinoma，HCC）是近年来发病率急剧上升的恶性肿瘤之一。 肝癌细胞系广泛应用于各类肝癌的研究。 肝癌细胞系的基因组与健康人细胞系的基因组不同。

The HCC cell line HLE, epithelial-like cells, established from HCC patient in 1975 by Dr Dor was used in this study. HLE was cultured in RPMI1640 (Sigma, Saint Louis, USA) media …

2018年9月3日 · Metabolomics revealed that the genomic portrait of HLE cells co-exist with profound reliance on glutamine to fuel tricarboxylic acid cycle, whereas HUH7 cells use both …

2022年11月24日 · Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among the events frequently occurring in hepatocellular carcinoma …

Results: The differential expression of cell cycle/growth regulator in hepatocellular carcinoma (HCC) showed a stronger tendency toward cell proliferation with more than 1.5-fold up …

2018年3月7日 · Galunisertib modulated the expression of stemness-related genes only in the invasive (HLE and HLF) HCC cells inducing a decreased expression of CD44 and THY1. …

2018年5月3日 · Our research revealed that HCC-derived exosomes could mediate EMT and enhance malignancy of HCC cells, suggesting that they may be novel diagnostic markers and …

2024年6月15日 · Based on transcriptome and classic CNA data, analysis of HCC samples (n = 364) indicated that PWP1 was homozygously deleted (Homdel) in 44 patients, heterozygously …

Objectives: Hepatocellular carcinoma (HCC) and cholangiolar carcinoma (CC) cell lines are used to analyze the basic mechanisms of carcinogenesis and target therapies. However, it is not yet …