2018年11月29日 · Percentage of CD68-positive cells or S100B/CD68 ratio did not add relevant information. The high specificity of S100B expression by immunohistochemistry indicates it may be an additional diagnostic feature of HLH. Of note, the test is available in routine immunohistochemistry laboratories.

2018年4月29日 · In this case series, we report two cases of HLH that illustrate the difficulty of making this diagnosis and a brief review of the literature on its pathophysiology, clinical presentation, diagnosis, and a subsequent therapeutic approach. Keywords: adult; cd68; hemophagocytic lymphohistiocytosis; hlh.

2018年11月29日 · Percentage of CD68-positive cells or S100B/CD68 ratio did not add relevant information. The high specificity of S100B expression by immunohistochemistry indicates it may be an additional diagnostic feature of HLH. Of note, the test is available in routine immunohistochemistry laboratories.

2023年3月1日 · Patients with hemophagocytosis in BM aspirate smears were assigned to HLH (n = 127) and non-HLH (n = 203) groups. We quantified hematoxylin-eosin and CD68 immunohistochemical staining of their trephine biopsies.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon life-threatening disorder characterized by wide spread non-neoplastic proliferation and inappropriate activation of mature macrophages resulting in hypercytokinemia. This uncontrollable and ...

In primary, pediatric forms of HLH, liver histopathology shows a characteristic pattern with a portal and sinusoidal infiltrate of CD3+, CD8+, granzyme B+ lymphocytes admixed with CD68+, CD1a- (benign but activated) histiocytes that exhibit hemophagocytosis [18, 19].

2024年1月24日 · Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterised by persistently activated cytotoxic lymphocytes and macrophages, which, if untreated, leads to multiorgan dysfunction and death. HLH should be considered in any acutely unwell patient not responding to treatment …

2018年11月29日 · 病例临床分类为 hlh 诊断（≥5 个标准）、临床可能（<5 个标准、但临床表现一致）或临床上无可疑（<5 个标准且临床表现与 hlh 不一致）。 进行 S100B 和 CD68 染色。

2021年12月8日 · Recently, glomerular infiltration by macrophages with endothelial cell injury has been reported in hemophagocytic lymphohistiocytosis (HLH), and this lesion is termed histiocytic glomerulopathy. 1-3 Here, we describe a rare case of HLH-associated histiocytic glomerulopathy.

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive life-threatening disease that involves uncontrolled activated lymphocytes and macrophages that secrete excessive cytokines. HLH includes various clinical situations that affect both children and adults, and its diagnosis and therapy are challenging. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8