In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding. [1] The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins.

高迁移率族蛋白B1(high mobility group box 1 protein, HMGB 1)是巨噬细胞释放出一种核蛋白。HMGB家族有3个成员，即HMGB1、HMGB2和HMGB3，三者在氨基酸序列上有80%的一致性。HMGB1是含量最丰富的HMG蛋白，在典型的…

High mobility group (HMG) box proteins are abundant and ubiquitous DNA binding proteins with a remarkable array of functions throughout the cell. The structure of the HMG box DNA binding domain and general mechanisms of DNA binding and bending have been known for …

High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. [1] HMG proteins were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels. [2]

rna聚合酶Ⅰ相关的转录分子ubf的dna结合结构域是85个氨基酸残基的重复区，与hmg1和hmg2的a、b结构相似，所以这种特征性结构被命名为“hmg结构域”。 网页 新闻 贴吧 知道 网盘 图片 视频 地图 文库 资讯 采购 百科

In the context of Neuroscience, 'HMG-box' refers to a domain containing protein that plays a role in maintaining chromosomal architecture in eukaryotes, including plants. It is subdivided into different families, such as HMGB, SSRP1, ARID-HMG, and 3xHMG-box, with specific functions in mitotic chromosome formation.

2007年6月29日 · HMG-box domains mediate either non-sequence-specific (e.g., HMGB-type proteins) or sequence-specific (e.g., transcription factors) DNA binding. Both types of HMG-box domains bind non-B-type DNA structures (bent, kinked and unwound) with high affinity. In addition, HMG-box domains are involved in a variety of protein-protein interactions.

Each HMGB (HMGB1-4) contains two DNA binding domains (termed HMG boxes A and B). HMGB1–3 has an acidic C-terminal tail, whereas HMGB4 lacks this tail (Thomas, 2001). Each HMGB box binds to DNA without any significant sequence specificity and can induce DNA conformational and structural changes (Agresti and Bianchi, 2003; Ueda and Yoshida, 2010).

摘要 哺乳动物高迁移率族蛋白(high mobility group box,HMGB)是一种含有两个串联的HMG box为主要特征的非组蛋白染色体DNA结合蛋白.HMGB参与许多生物学过程,包括染色质重塑、基因复制与转录调控...

High mobility group (HMG) box proteins are abundant and ubiquitous DNA binding proteins with a remarkable array of functions throughout the cell. The structure of the HMG-box DNA binding domain and general mechanisms of DNA binding and bending have been known for …