Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, resulting in the production of aldehydes, such as malondialdehyde and 4-hydroxy-2-nonenal (4-HNE) and other toxic substances.

2023年9月1日 · RPE cell death was induced both in vitro and ex vivo by 4-Hydroxynonenal (4-HNE), a major product of lipid peroxidation, sodium iodate (NaIO3) that has been widely used to model RPE cell death in dry AMD, a ferroptosis inducer RAS-selective lethal 3 (RSL3) or a necroptosis inducer shikonin.

Oxidative stress and subsequent chronic inflammation result in dysfunction of the retinal pigment epithelium (RPE) and represent therapeutic targets in the context of age-related macular degeneration (AMD). However, molecular mechanisms that linked oxidative stress and inflammation still unclear.

4-羟基-2-壬烯醛（英語： 4-hydroxy-2-nonenal ，或4-Hydroxynonenal，缩写4-HNE或HNE）是一种α,β-不饱和烯醛，是细胞脂质过氧化的主要不饱和烯醛产物，1991年由Esterbauer发现 [2] 。

2019年9月25日 · Exacerbated oxidative stress in RPE contributes to AMD 8 eliciting decomposition of polyunsaturated fatty acid and the formation of 4-hydroxy-2-nonenal (4-HNE), a highly reactive but relatively...

2023年8月6日 · RPE 细胞死亡由 4-Hydroxynonenal (4-HNE)（脂质过氧化的主要产物）和碘酸钠 (NaIO) 诱导，碘酸钠 (NaIO) 已广泛用于模拟干性 AMD 中的 RPE 细胞死亡，这是一种铁死亡诱导剂 RAS 选择性致死3 (RSL3) 或坏死性凋亡诱导剂紫草素。

氧化应激和随后的慢性炎症导致视网膜色素上皮（rpe）的功能障碍，并在与年龄有关的黄斑变性（amd）的背景下成为治疗靶标。 然而，将氧化应激和炎症联系起来的分子机制仍不清楚。

2019年11月1日 · Arimoclomol, an inducer of HSP70, significantly inhibited 4-HNE-mediated inflammation, indicating that HSP70 may be a potential target for controlling inflammation in the context of AMD progression. As an important mediator of oxidative stress, 4-HNE induces lysosome dysregulation, lipofuscin generation and apoptosis of RPE cells ( Ambati et al ...

Purpose: Oxidative damage to proteins, lipids, and DNA has been suggested to be a mechanism for age-related macular degeneration (AMD). The retina is particularly susceptible to lipid peroxidation due to high concentrations of easily oxidized polyunsaturated fatty acids in the presence of abundant oxygen.

2022年3月23日 · Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, resulting in...