Sep 16, 2014 · The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being revealed as a central signaling mediator during osmoregulation in the budding yeast Saccharomyces cerevisiae....

Sep 16, 2014 · The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being revealed as a central signaling mediator during osmoregulation in the budding yeast Saccharomyces cerevisiae. Homologs of Hog1 exist in all evaluated eukaryotic organisms, and this kinase plays a central role in …

Upon osmostress, activated Hog1 orchestrates several cellular functions to coordinate the adaptive response and maximize cell survival. Once activated, Hog1 controls mRNA biogenesis in both the nucleus and the cytoplasm. In the nucleus, Hog1 associates with stress-responsive loci to modulate transcription initiation and elongation.

The high-osmolarity glycerol (HOG) signalling pathway, comprising Ste11/Ssk2/Ssk22 (MAPKKK), Pbs2 (MAPKK), and Hog1 (MAPK), is an important and conserved pathway in fungi. However, the functions and downstream regulatory factors of Hog1 in nematode-trapping (NT) fungi remain poorly understood.

Oct 18, 2006 · Hog1p is a mitogen-activated protein kinase (MAPK) integral to the osmoregulatory signal transduction cascade (HOG signaling pathway) which affects gene expression, G1 and G2 cell cycle progression, and cellular ion levels in response to hyperosmotic stress (1 and a comprehensive review of the HOG pathway can be found in 12).

丝裂原活化蛋白激酶(MAPK)信号通路广泛存在于真核细胞并且高度保守,是生物体内非常重要的信号转导系统之一.胞外刺激信号通过细胞膜上的特异性受体传递给胞内MAPK信号通路,该信号通路通过磷酸化下游转录因子,调节各种酶类来调控转录水平及生化反应等,进而 ...

In response to hyperosmotic environments, most eukaryotic cells activate a specialized mitogen-activated protein (MAP) kinase pathway. In S. cerevisiae, the key protein kinase, Hog1, coordinates the transcriptional induction of a variety of genes devoted to osmoadaptation and general stress protection.

Apr 29, 2023 · Hog1 activation is needed to re-establish the balance between internal and external pressures upon osmotic shock. Upon exposure of cells to high osmolarity conditions, the two membrane-localized...

The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being revealed as a central signaling mediator during osmoregulation in the budding yeast Saccharomyces cerevisiae . Homo-logs of Hog1 exist in all evaluated e ukaryotic organisms, and this kinase plays a central role in cellular

蛋白激酶Hog1（高渗透压甘油1）是20年前发现的，在芽生酵母酿酒酵母中作为渗透压调节过程中的主要信号传导介质被发现。 Hog1的同源物存在于所有评估的真核生物中，并且该激酶在细胞对外部压力和刺激的反应中起着核心作用。